eprintid: 1508666 rev_number: 38 eprint_status: archive userid: 608 dir: disk0/01/50/86/66 datestamp: 2016-08-27 22:40:29 lastmod: 2021-12-05 00:33:36 status_changed: 2016-11-08 15:25:21 type: article metadata_visibility: show creators_name: Shamshiri, EA creators_name: Tierney, TM creators_name: Centeno, M creators_name: St Pier, K creators_name: Pressler, RM creators_name: Sharp, DJ creators_name: Perani, S creators_name: Cross, JH creators_name: Carmichael, DW title: Interictal activity is an important contributor to abnormal intrinsic network connectivity in paediatric focal epilepsy ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F83 divisions: D13 divisions: G26 keywords: EEG-fMRI, epilepsy, functional connectivity, interictal epileptiform discharges, intrinsic connectivity networks note: This is the peer reviewed version of the following article: Shamshiri, EA; Tierney, TM; Centeno, M; St Pier, K; Pressler, RM; Sharp, DJ; Perani, S; (2016) Interictal activity is an important contributor to abnormal intrinsic network connectivity in paediatric focal epilepsy, Human Brain Mapping, which has been published in final form at: http://dx.doi.org/10.1002/hbm.23356. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html#terms). abstract: Patients with focal epilepsy have been shown to have reduced functional connectivity in intrinsic connectivity networks (ICNs), which has been related to neurocognitive development and outcome. However, the relationship between interictal epileptiform discharges (IEDs) and changes in ICNs remains unclear, with evidence both for and against their influence. EEG-fMRI data was obtained in 27 children with focal epilepsy (mixed localisation and aetiologies) and 17 controls. A natural stimulus task (cartoon blocks verses blocks where the subject was told "please wait") was used to enhance the connectivity within networks corresponding to ICNs while reducing potential confounds of vigilance and motion. Our primary hypothesis was that the functional connectivity within visual and attention networks would be reduced in patients with epilepsy. We further hypothesized that controlling for the effects of IEDs would increase the connectivity in the patient group. The key findings were: (1) Patients with mixed epileptic foci showed a common connectivity reduction in lateral visual and attentional networks compared with controls. (2) Having controlled for the effects of IEDs there were no connectivity differences between patients and controls. (3) A comparison within patients revealed reduced connectivity between the attentional network and basal ganglia associated with interictal epileptiform discharges. We also found that the task activations were reduced in epilepsy patients but that this was unrelated to IED occurrence. Unexpectedly, connectivity changes in ICNs were strongly associated with the transient effects of interictal epileptiform discharges. Interictal epileptiform discharges were shown to have a pervasive transient influence on the brain's functional organisation. date: 2017-01 date_type: published official_url: http://dx.doi.org/10.1002/hbm.23356 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1154725 doi: 10.1002/hbm.23356 lyricists_name: Carmichael, David lyricists_name: Cross, Judith lyricists_name: Pressler, Ronit lyricists_name: Shamshiri, Elhum lyricists_name: Tierney, Timothy lyricists_id: DWCAR66 lyricists_id: JHCRO62 lyricists_id: RPRES06 lyricists_id: SHAMS60 lyricists_id: TIERN27 full_text_status: public publication: Human Brain Mapping volume: 38 number: 1 pagerange: 221-236 event_location: United States issn: 1097-0193 citation: Shamshiri, EA; Tierney, TM; Centeno, M; St Pier, K; Pressler, RM; Sharp, DJ; Perani, S; ... Carmichael, DW; + view all <#> Shamshiri, EA; Tierney, TM; Centeno, M; St Pier, K; Pressler, RM; Sharp, DJ; Perani, S; Cross, JH; Carmichael, DW; - view fewer <#> (2017) Interictal activity is an important contributor to abnormal intrinsic network connectivity in paediatric focal epilepsy. Human Brain Mapping , 38 (1) pp. 221-236. 10.1002/hbm.23356 <https://doi.org/10.1002/hbm.23356>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1508666/1/Shamshiri_Final_Resubmit_Shamshiri_et_al.pdf