eprintid: 1508576
rev_number: 32
eprint_status: archive
userid: 608
dir: disk0/01/50/85/76
datestamp: 2017-02-03 15:24:43
lastmod: 2021-11-29 00:12:35
status_changed: 2017-02-03 15:24:43
type: article
metadata_visibility: show
creators_name: Parker, LK
creators_name: Ponte, C
creators_name: Howell, KJ
creators_name: Ong, VH
creators_name: Denton, CP
creators_name: Schreiber, BE
title: Clinical features and management of erythromelalgia: long term follow-up of 46 cases
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G90
note: © Copyright Clinical and
Experimental Rheumatology 2017.
abstract: OBJECTIVES: To review our clinical experience of this rare condition and describe the clinical features and response to therapy in a cohort of patients with erythromelalgia (EM), a rare condition, characterised by paroxysmal hyperthermia of the extremities with erythema, pain and intense burning. METHODS: A review was made of the electronic and paper medical records of patients with the diagnosis of EM, with a telephone interview to verify and complete clinical information relating treatment and outcome. RESULTS: 46 patients (41 females) were included in this study. Mean age was 57 years and mean duration of symptoms was 16 years. Raynaud's phenomenon was present in 36 patients (80%) and 4 patients (9%) had systemic sclerosis. Smoking (current or previous) was identified as a possible risk factor in 26 cases and exposure to chronic vibration in 3 cases. Overall, the effect on quality of life was mild in 15% of cases, moderate in 30% and severe in 48%. The most common symptoms were burning (96%), heat (93%), pain (87%), and redness (83%). Symptoms affected the lower limbs in 98% of cases, upper limbs in 76%, face in 20% and trunk in 11%. Triggers included heat (85%), exercise (78%) and time of day (76%). Various medications were tried, showing poor effect in most cases. Intravenous iloprost was given to 27 patients, with benefit in 17 patients (63%). CONCLUSIONS: Erythromelalgia is a rare chronic debilitating condition. Exercise, heat and night time are common triggers. Current medical therapies are seldom effective and further research is sorely needed.
date: 2017-01-26
date_type: published
official_url: http://www.clinexprheumatol.org/abstract.asp?a=10493
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1148900
pii: 10493
lyricists_name: Denton, Christopher
lyricists_name: Howell, Kevin
lyricists_name: Ong, Voon
lyricists_name: Schreiber, Benjamin
lyricists_id: CPDEN87
lyricists_id: KHOWE18
lyricists_id: VONGX45
lyricists_id: BESCH99
actors_name: Denton, Christopher
actors_id: CPDEN87
actors_role: owner
full_text_status: public
publication: Clinical and Experimental Rheumatology
volume: 35
number: 1
pagerange: 80-84
event_location: Italy
issn: 0392-856X
citation:        Parker, LK;    Ponte, C;    Howell, KJ;    Ong, VH;    Denton, CP;    Schreiber, BE;      (2017)    Clinical features and management of erythromelalgia: long term follow-up of 46 cases.                   Clinical and Experimental Rheumatology , 35  (1)   pp. 80-84.          Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1508576/1/CER9395%20Parker%20et%20al%20%E2%80%93%20Clinical%20features%20and%20management%20of%20erythromelalgia.pdf