eprintid: 1508162
rev_number: 25
eprint_status: archive
userid: 608
dir: disk0/01/50/81/62
datestamp: 2017-01-19 10:51:37
lastmod: 2021-11-29 23:50:29
status_changed: 2017-01-19 10:51:37
type: article
metadata_visibility: show
creators_name: Palachanis, D
creators_name: Szabó, A
creators_name: Merks, RMH
title: Particle-based simulation of ellipse-shaped particle aggregation as a model for vascular network formation
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
keywords: Vasculogenesis; Cell-based model; Cell elongation; Morphogenesis; Alignment order
note: Copyright © 2015 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
abstract: Computational modeling is helpful for elucidating the cellular mechanisms driving biological morphogenesis. Previous simulation studies of blood vessel growth based on the cellular Potts model proposed that elongated, adhesive or mutually attractive endothelial cells suffice for the formation of blood vessel sprouts and vascular networks. Because each mathematical representation of a model introduces potential artifacts, it is important that model results are reproduced using alternative modeling paradigms. Here, we present a lattice-free, particle-based simulation of the cell elongation model of vasculogenesis. The new, particle-based simulations confirm the results obtained from the previous cellular Potts simulations. Furthermore, our current findings suggest that the emergence of order is possible with the application of a high enough attractive force or, alternatively, a longer attraction radius. The methodology will be applicable to a range of problems in morphogenesis and noisy particle aggregation in which cell shape is a key determining factor.
date: 2015-12
date_type: published
official_url: http://doi.org/10.1007/s40571-015-0064-5
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1149559
doi: 10.1007/s40571-015-0064-5
lyricists_name: Szabo, Andras
lyricists_id: ASZAB39
actors_name: Szabo, Andras
actors_id: ASZAB39
actors_role: owner
full_text_status: public
publication: Computational Particle Mechanics
volume: 2
number: 4
pagerange: 371-379
issn: 2196-4386
citation:        Palachanis, D;    Szabó, A;    Merks, RMH;      (2015)    Particle-based simulation of ellipse-shaped particle aggregation as a model for vascular network formation.                   Computational Particle Mechanics , 2  (4)   pp. 371-379.    10.1007/s40571-015-0064-5 <https://doi.org/10.1007/s40571-015-0064-5>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1508162/1/Szabo_art%25253A10.1007%25252Fs40571-015-0064-5.pdf