eprintid: 1506347
rev_number: 26
eprint_status: archive
userid: 608
dir: disk0/01/50/63/47
datestamp: 2016-07-30 21:29:27
lastmod: 2021-12-13 02:37:45
status_changed: 2016-08-09 17:38:14
type: article
metadata_visibility: show
creators_name: Valente, V
creators_name: Demosthenous, A
title: Wideband Fully-Programmable Dual-Mode CMOS Analogue Front-End for Electrical Impedance Spectroscopy
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F46
keywords: analogue readout, electrical impedance spectroscopy (EIS), integrated circuits
note: Copyright © 2016 The authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
abstract: This paper presents a multi-channel dual-mode CMOS analogue front-end (AFE) for electrochemical and bioimpedance analysis. Current-mode and voltage-mode readouts, integrated on the same chip, can provide an adaptable platform to correlate single-cell biosensor studies with large-scale tissue or organ analysis for real-time cancer detection, imaging and characterization. The chip, implemented in a 180-nm CMOS technology, combines two current-readout (CR) channels and four voltage-readout (VR) channels suitable for both bipolar and tetrapolar electrical impedance spectroscopy (EIS) analysis. Each VR channel occupies an area of 0.48 mm 2 , is capable of an operational bandwidth of 8 MHz and a linear gain in the range between -6 dB and 42 dB. The gain of the CR channel can be set to 10 kΩ, 50 kΩ or 100 kΩ and is capable of 80-dB dynamic range, with a very linear response for input currents between 10 nA and 100 μ A. Each CR channel occupies an area of 0.21 mm 2 . The chip consumes between 530 μ A and 690 μ A per channel and operates from a 1.8-V supply. The chip was used to measure the impedance of capacitive interdigitated electrodes in saline solution. Measurements show close matching with results obtained using a commercial impedance analyser. The chip will be part of a fully flexible and configurable fully-integrated dual-mode EIS system for impedance sensors and bioimpedance analysis.
date: 2016-08
date_type: published
official_url: http://dx.doi.org/10.3390/s16081159
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1144870
doi: 10.3390/s16081159
pii: s16081159
lyricists_name: Demosthenous, Andreas
lyricists_name: Valente, Virgilio
lyricists_id: ACDEM08
lyricists_id: VVALE57
full_text_status: public
publication: Sensors
volume: 16
number: 8
article_number: 1159
event_location: Switzerland
issn: 1424-8220
citation:        Valente, V;    Demosthenous, A;      (2016)    Wideband Fully-Programmable Dual-Mode CMOS Analogue Front-End for Electrical Impedance Spectroscopy.                   Sensors , 16  (8)    , Article 1159.  10.3390/s16081159 <https://doi.org/10.3390/s16081159>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1506347/1/Valente%20and%20Demosthenous%20Wideband%20Fully-Programmable%20Dual-Mode%20CMOS%20Analogue%20Front-End%20for%20Electrical%20Impedance%20Spectroscopy%20VoR.pdf