eprintid: 1506126
rev_number: 27
eprint_status: archive
userid: 608
dir: disk0/01/50/61/26
datestamp: 2016-07-30 20:54:14
lastmod: 2021-09-19 22:33:18
status_changed: 2016-11-04 14:24:34
type: article
metadata_visibility: show
creators_name: Huntley, JD
creators_name: Hampshire, A
creators_name: Bor, D
creators_name: Owen, AM
creators_name: Howard, RJ
title: The importance of sustained attention in early Alzheimer's disease
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D79
keywords: Alzheimer's disease, attention, cognition, neuropsychology
note: This is the peer reviewed version of the following article: Huntley, JD; Hampshire, A; Bor, D; Owen, AM; Howard, RJ; (2016) The importance of sustained attention in early Alzheimer's disease, International Journal of Geriatric Society, which has been published in final form at: http://dx.doi.org/10.1002/gps.4537. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html#terms).
abstract: INTRODUCTION: There is conflicting evidence regarding impairment of sustained attention in early Alzheimer's disease (AD). We examine whether sustained attention is impaired and predicts deficits in other cognitive domains in early AD. METHODS: Fifty-one patients with early AD (MMSE > 18) and 15 healthy elderly controls were recruited. The sustained attention to response task (SART) was used to assess sustained attention. A subset of 25 patients also performed tasks assessing general cognitive function (ADAS-Cog), episodic memory (Logical memory scale, Paired Associates Learning), executive function (verbal fluency, grammatical reasoning) and working memory (digit and spatial span). RESULTS: AD patients were significantly impaired on the SART compared to healthy controls (total error β = 19.75, p = 0.027). SART errors significantly correlated with MMSE score (Spearman's rho = -0.338, p = 0.015) and significantly predicted deficits in ADAS-Cog (β = 0.14, p = 0.004). DISCUSSIONS: Patients with early AD have significant deficits in sustained attention, as measured using the SART. This may impair performance on general cognitive testing, and therefore should be taken into account during clinical assessment, and everyday management of individuals with early AD.
date: 2017-08
date_type: published
official_url: http://dx.doi.org/10.1002/gps.4537
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1143670
doi: 10.1002/gps.4537
lyricists_name: Howard, Robert
lyricists_name: Huntley, Jonathan
lyricists_id: RJMWH01
lyricists_id: JHUNT57
full_text_status: public
publication: International Journal of Geriatric Society
volume: 32
number: 8
pagerange: 860-867
issn: 1099-1166
citation:        Huntley, JD;    Hampshire, A;    Bor, D;    Owen, AM;    Howard, RJ;      (2017)    The importance of sustained attention in early Alzheimer's disease.                   International Journal of Geriatric Society , 32  (8)   pp. 860-867.    10.1002/gps.4537 <https://doi.org/10.1002/gps.4537>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1506126/1/Howard_Huntley%20et%20al%20IJGPsych.pdf