eprintid: 1504678 rev_number: 35 eprint_status: archive userid: 608 dir: disk0/01/50/46/78 datestamp: 2016-07-24 04:30:13 lastmod: 2021-12-05 00:49:00 status_changed: 2016-09-29 13:59:18 type: article metadata_visibility: show creators_name: Temple, JL creators_name: Cordero, P creators_name: Li, J creators_name: Vi, N creators_name: Oben, JA title: A Guide to Non-Alcoholic Fatty Liver Disease in Childhood and Adolescence ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D17 divisions: D13 keywords: Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Biochemistry & Molecular Biology, Chemistry, Multidisciplinary, Chemistry, NAFLD, steatosis, obesity, children, adolescent, RANDOMIZED CONTROLLED-TRIAL, METABOLIC SYNDROME CRITERIA, PLACEBO-CONTROLLED TRIAL, OBESE CHILDREN, HEPATIC STEATOSIS, URSODEOXYCHOLIC ACID, VITAMIN-E, INSULIN-RESISTANCE, BARIATRIC SURGERY, LIFE-STYLE note: Copyright © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). abstract: Non-Alcoholic Fatty Liver Disease (NAFLD) is now the most prevalent form of chronic liver disease, affecting 10%–20% of the general paediatric population. Within the next 10 years it is expected to become the leading cause of liver pathology, liver failure and indication for liver transplantation in childhood and adolescence in the Western world. While our understanding of the pathophysiological mechanisms underlying this disease remains limited, it is thought to be the hepatic manifestation of more widespread metabolic dysfunction and is strongly associated with a number of metabolic risk factors, including insulin resistance, dyslipidaemia, cardiovascular disease and, most significantly, obesity. Despite this, ”paediatric” NAFLD remains under-studied, under-recognised and, potentially, undermanaged. This article will explore and evaluate our current understanding of NAFLD in childhood and adolescence and how it differs from adult NAFLD, in terms of its epidemiology, pathophysiology, natural history, diagnosis and clinical management. Given the current absence of definitive radiological and histopathological diagnostic tests, maintenance of a high clinical suspicion by all members of the multidisciplinary team in primary and specialist care settings remains the most potent of diagnostic tools, enabling early diagnosis and appropriate therapeutic intervention. date: 2016-06-01 date_type: published publisher: MDPI AG official_url: http://dx.doi.org/10.3390/ijms17060947 oa_status: green full_text_type: pub pmcid: PMC4926480 language: eng primo: open primo_central: open_green article_type_text: Review verified: verified_manual elements_id: 1139832 doi: 10.3390/ijms17060947 language_elements: English lyricists_name: Cordero Sanchez, Paul lyricists_name: Li, Jiawei lyricists_name: Oben, Jude lyricists_id: PCORD16 lyricists_id: CLIXX61 lyricists_id: JAOBE76 actors_name: Barczynska, Patrycja actors_id: PBARC91 actors_role: owner full_text_status: public publication: International Journal of Molecular Sciences volume: 17 number: 6 article_number: 947 pages: 36 issn: 1422-0067 citation: Temple, JL; Cordero, P; Li, J; Vi, N; Oben, JA; (2016) A Guide to Non-Alcoholic Fatty Liver Disease in Childhood and Adolescence. International Journal of Molecular Sciences , 17 (6) , Article 947. 10.3390/ijms17060947 <https://doi.org/10.3390/ijms17060947>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1504678/1/A%20Guide%20to%20Non-Alcoholic%20Fatty%20Liver%20Disease%20in%20Childhood%20and%20Adolescence.pdf