@article{discovery1503795, note = {Copyright {\copyright} 2016 The Author(s). Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.}, month = {January}, pages = {84--94}, journal = {Journal of Sol-Gel Science and Technology}, volume = {81}, year = {2017}, title = {Lithium-silicate sol-gel bioactive glass and the effect of lithium precursor on structure-property relationships}, number = {1}, abstract = {This work reports the synthesis of lithium-silicate glass, containing 10 mol\% of Li22O by the sol-gel process, intended for the regeneration of cartilage. Lithium citrate and lithium nitrate were selected as lithium precursors. The effects of the lithium precursor on the sol-gel process, and the resulting glass structure, morphology, dissolution behaviour, chondrocyte viability and proliferation, were investigated. When lithium citrate was used, mesoporous glass containing lithium as a network modifier was obtained, whereas the use of lithium nitrate produced relatively dense glass-ceramic with the presence of lithium metasilicate, as shown by X-ray diffraction, 2929Si and 77Li MAS NMR and nitrogen sorption data. Nitrate has a better affinity for lithium than citrate, leading to heterogeneous crystallisation from the mesopores, where lithium salts precipitated during drying. Citrate decomposed at a lower temperature, where the crystallisation of lithium-silicate crystal is not thermodynamically favourable. Upon decomposition of the citrate, a solid-state salt metathesis reaction between citrate and silanol occurred, followed by the diffusion of lithium within the structure of the glass. Both glass and glass-ceramic released silica and lithium ions in culture media, but release rate was lower for the glass-ceramic. Both samples did not affect chondrocyte viability and proliferation.}, url = {http://dx.doi.org/10.1007/s10971-016-4097-x}, author = {Ma{\cc}on, ALB and Jacquemin, M and Page, SJ and Li, S and Bertazzo, S and Stevens, MM and Hanna, JV and Jones, JR}, keywords = {Bioactive glass; Lithium; Sol-gel}, issn = {1573-4846} }