@incollection{discovery1503787, title = {Gefitinib}, note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.}, publisher = {nova science publishers}, number = {22}, year = {2016}, editor = {E Una-Cidon}, booktitle = {The Easy Book of Cancer Pharmacology}, month = {May}, author = {Una-Cidon, E and Adeleke, S and Masters, B and Wood, V}, abstract = {Gefitinib is a small molecule that specifically inhibits the tyrosine kinase (TK) activity of the epidermal growth factor receptor (EGFR) type 1 by interfering with the adenosine triphosphate (ATP) binding site. About 10\% of patient with non-small cell lung cancer (NSCLC) in the US and about 35\% in East Asia have EGFR mutations. [1] Hence gefitinib and the other EGFR inhibitor erlotinib are inevitably important in treatment of NSCLC, of the adenocarcinoma variant with the above mutation.}, url = {https://novapublishers.com/shop/the-easy-book-of-cancer-pharmacology/}, keywords = {Targeted agent, personalised medicine, precision medicine} }