eprintid: 1493366
rev_number: 33
eprint_status: archive
userid: 608
dir: disk0/01/49/33/66
datestamp: 2016-07-13 15:18:21
lastmod: 2021-12-23 23:02:28
status_changed: 2016-07-13 15:18:21
type: article
metadata_visibility: show
creators_name: Veloudi, P
creators_name: Blizzard, L
creators_name: Srikanth, VK
creators_name: McCartney, P
creators_name: Lukoshkova, EV
creators_name: Hughes, AD
creators_name: Head, GA
creators_name: Sharman, JE
title: Associations of blood pressure variability and retinal arteriolar diameter in participants with type 2 diabetes
ispublished: pub
divisions: UCL
divisions: B02
divisions: D14
divisions: GA3
keywords: Blood pressure variability; microcirculation; diabetes; arteriolar diameter
note: Copyright © The Author(s) 2016. Published by Sage Publications. The published version of record is available from the journal website at http://dx.doi.org/10.1177/1479164116633424
abstract: Blood pressure variability is associated with macrovascular complications and stroke, but its association with the microcirculation in type II diabetes has not been assessed. This study aimed to determine the relationship between blood pressure variability indices and retinal arteriolar diameter in non-diabetic and type II diabetes participants. Digitized retinal images were analysed to quantify arteriolar diameters in 35 non-diabetic (aged 52 ± 11 years; 49% male) and 28 type II diabetes (aged 61 ± 9 years; 50% male) participants. Blood pressure variability was derived from 24-h ambulatory blood pressure. Arteriolar diameter was positively associated with daytime rate of systolic blood pressure variation (p = 0.04) among type II diabetes participants and negatively among non-diabetics (p = 0.008; interaction p = 0.001). This finding was maintained after adjusting for age, sex, body mass index and mean daytime systolic blood pressure. These findings suggest that the blood pressure variability-related mechanisms underlying retinal vascular disease may differ between people with and without type II diabetes.
date: 2016-07
official_url: http://dx.doi.org/10.1177/1479164116633424
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Review
verified: verified_manual
elements_id: 1131034
doi: 10.1177/1479164116633424
lyricists_name: Hughes, Alun
lyricists_id: ADHUG42
actors_name: Hughes, Alun
actors_id: ADHUG42
actors_role: owner
full_text_status: public
publication: Diabetes and Vascular Disease Research
volume: 13
number: 4
pagerange: 299-302
issn: 1752-8984
citation:        Veloudi, P;    Blizzard, L;    Srikanth, VK;    McCartney, P;    Lukoshkova, EV;    Hughes, AD;    Head, GA;           Veloudi, P;  Blizzard, L;  Srikanth, VK;  McCartney, P;  Lukoshkova, EV;  Hughes, AD;  Head, GA;  Sharman, JE;   - view fewer <#>    (2016)    Associations of blood pressure variability and retinal arteriolar diameter in participants with type 2 diabetes.                   Diabetes and Vascular Disease Research , 13  (4)   pp. 299-302.    10.1177/1479164116633424 <https://doi.org/10.1177/1479164116633424>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1493366/1/NIHMS68593.pdf