eprintid: 1483147
rev_number: 41
eprint_status: archive
userid: 608
dir: disk0/01/48/31/47
datestamp: 2016-04-23 23:57:31
lastmod: 2021-09-17 22:35:42
status_changed: 2016-08-17 13:55:45
type: article
metadata_visibility: show
creators_name: Lam, C
creators_name: Chaddock, G
creators_name: Marciani, L
creators_name: Costigan, C
creators_name: Paul, J
creators_name: Cox, E
creators_name: Hoad, C
creators_name: Menys, A
creators_name: Pritchard, S
creators_name: Garsed, K
creators_name: Taylor, S
creators_name: Atkinson, D
creators_name: Gowland, P
creators_name: Spiller, R
title: Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: FI6
keywords: colon, functional constipation, irritable bowel syndrome with constipation, laxative, motility
note: Copyright © 2016 The Authors. This is an open access article under the terms of the Creative Commons Attribution License (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/),
which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
abstract: BACKGROUND: Functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C) share many symptoms but underlying mechanisms may be different. We have developed a magnetic resonance imaging (MRI) technique to measure intestinal volumes, transit, and motility in response to a laxative, Moviprep(®) . We aim to use these biomarkers to study the pathophysiology in IBS-C and FC. METHODS: Twenty-four FC and 24 IBS-C were studied. Transit was assessed using the weighted average position score (WAPS) of five MRI marker pills, taken 24 h before MRI scanning. Following baseline scan, participants ingested 1 L of Moviprep(®) followed by hourly scans. Magnetic resonance imaging parameters and bowel symptoms were scored from 0 to 4 h. KEY RESULTS: Weighted average position score for FC was 3.6 (2.5-4.2), significantly greater than IBS-C at 2.0 (1.5-3.2), p = 0.01, indicating slower transit for FC. Functional constipation showed greater fasting small bowel water content, 83 (63-142) mL vs 39 (15-70) mL in IBS-C, p < 0.01 and greater ascending colon volume (AC), 314 (101) mL vs 226 (71) mL in IBS-C, p < 0.01. FC motility index was lower at 0.055 (0.044) compared to IBS-C, 0.107 (0.070), p < 0.01. Time to first bowel movement following ingestion of Moviprep(®) was greater for FC, being 295 (116-526) min, compared to IBS-C at 84 (49-111) min, p < 0.01, and correlated with AC volume 2 h after Moviprep(®) , r = 0.44, p < 0.01. Using a cut-off >230 min distinguishes FC from IBS-C with low sensitivity of 55% but high specificity of 95%. CONCLUSION & INFERENCES: Our objective MRI biomarkers allow a distinction between FC and IBS-C.
date: 2016-06
date_type: published
official_url: http://dx.doi.org/10.1111/nmo.12784
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1113658
doi: 10.1111/nmo.12784
lyricists_name: Atkinson, David
lyricists_name: Menys, Alex
lyricists_name: Taylor, Stuart
lyricists_id: DATKI13
lyricists_id: AMENY77
lyricists_id: STAYL70
full_text_status: public
publication: Neurogastroenterology & Motility
volume: 28
number: 6
pagerange: 861-870
event_location: England
issn: 1365-2982
citation:        Lam, C;    Chaddock, G;    Marciani, L;    Costigan, C;    Paul, J;    Cox, E;    Hoad, C;                             ... Spiller, R; + view all <#>        Lam, C;  Chaddock, G;  Marciani, L;  Costigan, C;  Paul, J;  Cox, E;  Hoad, C;  Menys, A;  Pritchard, S;  Garsed, K;  Taylor, S;  Atkinson, D;  Gowland, P;  Spiller, R;   - view fewer <#>    (2016)    Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation.                   Neurogastroenterology & Motility , 28  (6)   pp. 861-870.    10.1111/nmo.12784 <https://doi.org/10.1111/nmo.12784>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1483147/1/Lam%20et%20al%20Colonic%20response%20to%20laxative%20ingestion%20as%20assessed%20by%20MRI%20differs%20in%20constipated%20irritable%20bowel%20syndrome%20compared%20to%20functional%20constipation.pdf
document_url: https://discovery.ucl.ac.uk/id/eprint/1483147/7/Lam%20et%20al%20Colonic%20response%20to%20laxative%20ingestion%20as%20assessed%20by%20MRI%20differs%20in%20constipated%20irritable%20bowel%20syndrome%20compared%20to%20functional%20constipation%20Supporting%20info.pdf