TY  - JOUR
EP  - 870
AV  - public
Y1  - 2016/06//
TI  - Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation
ID  - discovery1483147
N2  - BACKGROUND: Functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C) share many symptoms but underlying mechanisms may be different. We have developed a magnetic resonance imaging (MRI) technique to measure intestinal volumes, transit, and motility in response to a laxative, Moviprep(®) . We aim to use these biomarkers to study the pathophysiology in IBS-C and FC. METHODS: Twenty-four FC and 24 IBS-C were studied. Transit was assessed using the weighted average position score (WAPS) of five MRI marker pills, taken 24 h before MRI scanning. Following baseline scan, participants ingested 1 L of Moviprep(®) followed by hourly scans. Magnetic resonance imaging parameters and bowel symptoms were scored from 0 to 4 h. KEY RESULTS: Weighted average position score for FC was 3.6 (2.5-4.2), significantly greater than IBS-C at 2.0 (1.5-3.2), p = 0.01, indicating slower transit for FC. Functional constipation showed greater fasting small bowel water content, 83 (63-142) mL vs 39 (15-70) mL in IBS-C, p < 0.01 and greater ascending colon volume (AC), 314 (101) mL vs 226 (71) mL in IBS-C, p < 0.01. FC motility index was lower at 0.055 (0.044) compared to IBS-C, 0.107 (0.070), p < 0.01. Time to first bowel movement following ingestion of Moviprep(®) was greater for FC, being 295 (116-526) min, compared to IBS-C at 84 (49-111) min, p < 0.01, and correlated with AC volume 2 h after Moviprep(®) , r = 0.44, p < 0.01. Using a cut-off >230 min distinguishes FC from IBS-C with low sensitivity of 55% but high specificity of 95%. CONCLUSION & INFERENCES: Our objective MRI biomarkers allow a distinction between FC and IBS-C.
KW  - colon
KW  -  functional constipation
KW  -  irritable bowel syndrome with constipation
KW  -  laxative
KW  -  motility
VL  - 28
SP  - 861
N1  - Copyright © 2016 The Authors. This is an open access article under the terms of the Creative Commons Attribution License (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/),
which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
IS  - 6
SN  - 1365-2982
UR  - http://dx.doi.org/10.1111/nmo.12784
A1  - Lam, C
A1  - Chaddock, G
A1  - Marciani, L
A1  - Costigan, C
A1  - Paul, J
A1  - Cox, E
A1  - Hoad, C
A1  - Menys, A
A1  - Pritchard, S
A1  - Garsed, K
A1  - Taylor, S
A1  - Atkinson, D
A1  - Gowland, P
A1  - Spiller, R
JF  - Neurogastroenterology & Motility
ER  -