<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1483147> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/title> "Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: Functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C) share many symptoms but underlying mechanisms may be different. We have developed a magnetic resonance imaging (MRI) technique to measure intestinal volumes, transit, and motility in response to a laxative, Moviprep(®) . We aim to use these biomarkers to study the pathophysiology in IBS-C and FC. METHODS: Twenty-four FC and 24 IBS-C were studied. Transit was assessed using the weighted average position score (WAPS) of five MRI marker pills, taken 24 h before MRI scanning. Following baseline scan, participants ingested 1 L of Moviprep(®) followed by hourly scans. Magnetic resonance imaging parameters and bowel symptoms were scored from 0 to 4 h. KEY RESULTS: Weighted average position score for FC was 3.6 (2.5-4.2), significantly greater than IBS-C at 2.0 (1.5-3.2), p = 0.01, indicating slower transit for FC. Functional constipation showed greater fasting small bowel water content, 83 (63-142) mL vs 39 (15-70) mL in IBS-C, p < 0.01 and greater ascending colon volume (AC), 314 (101) mL vs 226 (71) mL in IBS-C, p < 0.01. FC motility index was lower at 0.055 (0.044) compared to IBS-C, 0.107 (0.070), p < 0.01. Time to first bowel movement following ingestion of Moviprep(®) was greater for FC, being 295 (116-526) min, compared to IBS-C at 84 (49-111) min, p < 0.01, and correlated with AC volume 2 h after Moviprep(®) , r = 0.44, p < 0.01. Using a cut-off >230 min distinguishes FC from IBS-C with low sensitivity of 55% but high specificity of 95%. CONCLUSION & INFERENCES: Our objective MRI biomarkers allow a distinction between FC and IBS-C."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/date> "2016-06" .
<https://discovery.ucl.ac.uk/id/document/253809> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/document/253815> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/volume> "28" .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/issue> "6" .
<https://discovery.ucl.ac.uk/id/publication/ext-13652982> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-13652982> <http://xmlns.com/foaf/0.1/name> "Neurogastroenterology & Motility"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/publication/ext-13652982> <http://purl.org/ontology/bibo/issn> "13652982" .
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<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1483147#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1483147#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-2f3d047abc6b0e89a725edbe1bf38ec7> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9fc810c1bfe93eff4e63bef296fd769d> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1483147#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1483147#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-9fc810c1bfe93eff4e63bef296fd769d> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7756d2b07f8df75bc685a038db475442> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1483147#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1483147#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-7756d2b07f8df75bc685a038db475442> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e365e9135f5b0fe74037232b507d3795> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1483147#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1483147#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-e365e9135f5b0fe74037232b507d3795> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7991eba6511aafab3784e1a285968cd1> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1483147#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1483147#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-7991eba6511aafab3784e1a285968cd1> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-746e3d4d95253a64528d7e1d9809ebb4> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1483147#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1483147#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-746e3d4d95253a64528d7e1d9809ebb4> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-45423e9413ab01b66e55d6c767bb190e> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1483147#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1483147#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-45423e9413ab01b66e55d6c767bb190e> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-88c8d12ac5f81cfb54a65f04a1b0312f> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1483147#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1483147#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-88c8d12ac5f81cfb54a65f04a1b0312f> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4c6124d3266f3d1e7c0d1b944ab4dfaa> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1483147#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1483147#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-4c6124d3266f3d1e7c0d1b944ab4dfaa> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-94919bee8e0dc18fe54261d812b546a5> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1483147#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1483147#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-94919bee8e0dc18fe54261d812b546a5> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7920e45f59fec621f18de863f65fe56a> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1483147#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1483147#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-7920e45f59fec621f18de863f65fe56a> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4bdd958caff00acdef8acf1b0e196542> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1483147#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1483147#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-4bdd958caff00acdef8acf1b0e196542> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-89728b8584dcab21ae90deb33b5dee26> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1483147#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1483147#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-89728b8584dcab21ae90deb33b5dee26> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6dddd0d039d89cdd256e0fceafaf85ad> .
<https://discovery.ucl.ac.uk/id/eprint/1483147> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1483147#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1483147#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-6dddd0d039d89cdd256e0fceafaf85ad> .
<https://discovery.ucl.ac.uk/id/person/ext-e365e9135f5b0fe74037232b507d3795> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e365e9135f5b0fe74037232b507d3795> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e365e9135f5b0fe74037232b507d3795> <http://xmlns.com/foaf/0.1/familyName> "Costigan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e365e9135f5b0fe74037232b507d3795> <http://xmlns.com/foaf/0.1/name> "C Costigan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6dddd0d039d89cdd256e0fceafaf85ad> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6dddd0d039d89cdd256e0fceafaf85ad> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6dddd0d039d89cdd256e0fceafaf85ad> <http://xmlns.com/foaf/0.1/familyName> "Spiller"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6dddd0d039d89cdd256e0fceafaf85ad> <http://xmlns.com/foaf/0.1/name> "R Spiller"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7991eba6511aafab3784e1a285968cd1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7991eba6511aafab3784e1a285968cd1> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7991eba6511aafab3784e1a285968cd1> <http://xmlns.com/foaf/0.1/familyName> "Paul"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7991eba6511aafab3784e1a285968cd1> <http://xmlns.com/foaf/0.1/name> "J Paul"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-746e3d4d95253a64528d7e1d9809ebb4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-746e3d4d95253a64528d7e1d9809ebb4> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-746e3d4d95253a64528d7e1d9809ebb4> <http://xmlns.com/foaf/0.1/familyName> "Cox"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-746e3d4d95253a64528d7e1d9809ebb4> <http://xmlns.com/foaf/0.1/name> "E Cox"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7756d2b07f8df75bc685a038db475442> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7756d2b07f8df75bc685a038db475442> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7756d2b07f8df75bc685a038db475442> <http://xmlns.com/foaf/0.1/familyName> "Marciani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7756d2b07f8df75bc685a038db475442> <http://xmlns.com/foaf/0.1/name> "L Marciani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4c6124d3266f3d1e7c0d1b944ab4dfaa> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4c6124d3266f3d1e7c0d1b944ab4dfaa> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4c6124d3266f3d1e7c0d1b944ab4dfaa> <http://xmlns.com/foaf/0.1/familyName> "Pritchard"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4c6124d3266f3d1e7c0d1b944ab4dfaa> <http://xmlns.com/foaf/0.1/name> "S Pritchard"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4bdd958caff00acdef8acf1b0e196542> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4bdd958caff00acdef8acf1b0e196542> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4bdd958caff00acdef8acf1b0e196542> <http://xmlns.com/foaf/0.1/familyName> "Atkinson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4bdd958caff00acdef8acf1b0e196542> <http://xmlns.com/foaf/0.1/name> "D Atkinson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-88c8d12ac5f81cfb54a65f04a1b0312f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-88c8d12ac5f81cfb54a65f04a1b0312f> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-88c8d12ac5f81cfb54a65f04a1b0312f> <http://xmlns.com/foaf/0.1/familyName> "Menys"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-88c8d12ac5f81cfb54a65f04a1b0312f> <http://xmlns.com/foaf/0.1/name> "A Menys"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9fc810c1bfe93eff4e63bef296fd769d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9fc810c1bfe93eff4e63bef296fd769d> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9fc810c1bfe93eff4e63bef296fd769d> <http://xmlns.com/foaf/0.1/familyName> "Chaddock"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9fc810c1bfe93eff4e63bef296fd769d> <http://xmlns.com/foaf/0.1/name> "G Chaddock"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-45423e9413ab01b66e55d6c767bb190e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-45423e9413ab01b66e55d6c767bb190e> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-45423e9413ab01b66e55d6c767bb190e> <http://xmlns.com/foaf/0.1/familyName> "Hoad"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-45423e9413ab01b66e55d6c767bb190e> <http://xmlns.com/foaf/0.1/name> "C Hoad"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-94919bee8e0dc18fe54261d812b546a5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-94919bee8e0dc18fe54261d812b546a5> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-94919bee8e0dc18fe54261d812b546a5> <http://xmlns.com/foaf/0.1/familyName> "Garsed"^^<http://www.w3.org/2001/XMLSchema#string> .
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