eprintid: 1482247
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/01/48/22/47
datestamp: 2016-07-11 15:56:46
lastmod: 2021-09-26 22:49:09
status_changed: 2016-07-11 15:56:46
type: article
metadata_visibility: show
creators_name: Taylor, PW
title: Impact of space flight on bacterial virulence and antibiotic susceptibility
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G08
keywords: International Space Station, Staphylococcus aureus, bacterial phenotypes, low-shear modeled microgravity, microgravity, spacecraft contamination
note: This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License (https://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
abstract: Manned space flight induces a reduction in immune competence among crew and is likely to cause deleterious changes to the composition of the gastrointestinal, nasal, and respiratory bacterial flora, leading to an increased risk of infection. The space flight environment may also affect the susceptibility of microorganisms within the spacecraft to antibiotics, key components of flown medical kits, and may modify the virulence characteristics of bacteria and other microorganisms that contaminate the fabric of the International Space Station and other flight platforms. This review will consider the impact of true and simulated microgravity and other characteristics of the space flight environment on bacterial cell behavior in relation to the potential for serious infections that may appear during missions to astronomical objects beyond low Earth orbit.
date: 2015-07-30
date_type: published
official_url: http://dx.doi.org/10.2147/IDR.S67275
oa_status: green
full_text_type: pub
pmcid: PMC4524529
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1045488
doi: 10.2147/IDR.S67275
pii: idr-8-249
lyricists_name: Taylor, Peter
lyricists_id: PTAYL42
actors_name: Taylor, Peter
actors_id: PTAYL42
actors_role: owner
full_text_status: public
publication: Infection and Drug Resistance
volume: 2015
number: 8
pagerange: 249-262
event_location: New Zealand
issn: 1178-6973
citation:        Taylor, PW;      (2015)    Impact of space flight on bacterial virulence and antibiotic susceptibility.                   Infection and Drug Resistance , 2015  (8)   pp. 249-262.    10.2147/IDR.S67275 <https://doi.org/10.2147/IDR.S67275>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1482247/1/Impact%20of%20space%20flight%20on%20bacterial%20virulence%20and%20antibiotic%20susceptibility.pdf