TY  - JOUR
SP  - 249
VL  - 2015
IS  - 8
N1  - This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License (https://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
UR  - http://dx.doi.org/10.2147/IDR.S67275
SN  - 1178-6973
JF  - Infection and Drug Resistance
A1  - Taylor, PW
TI  - Impact of space flight on bacterial virulence and antibiotic susceptibility
AV  - public
Y1  - 2015/07/30/
EP  - 262
N2  - Manned space flight induces a reduction in immune competence among crew and is likely to cause deleterious changes to the composition of the gastrointestinal, nasal, and respiratory bacterial flora, leading to an increased risk of infection. The space flight environment may also affect the susceptibility of microorganisms within the spacecraft to antibiotics, key components of flown medical kits, and may modify the virulence characteristics of bacteria and other microorganisms that contaminate the fabric of the International Space Station and other flight platforms. This review will consider the impact of true and simulated microgravity and other characteristics of the space flight environment on bacterial cell behavior in relation to the potential for serious infections that may appear during missions to astronomical objects beyond low Earth orbit.
ID  - discovery1482247
KW  - International Space Station
KW  -  Staphylococcus aureus
KW  -  bacterial phenotypes
KW  -  low-shear modeled microgravity
KW  -  microgravity
KW  -  spacecraft contamination
ER  -