eprintid: 1481113
rev_number: 27
eprint_status: archive
userid: 608
dir: disk0/01/48/11/13
datestamp: 2016-04-17 13:42:08
lastmod: 2021-10-15 23:00:55
status_changed: 2016-04-21 14:46:24
type: article
metadata_visibility: show
creators_name: Huys, QJ
creators_name: Gölzer, M
creators_name: Friedel, E
creators_name: Heinz, A
creators_name: Cools, R
creators_name: Dayan, P
creators_name: Dolan, RJ
title: The specificity of Pavlovian regulation is associated with recovery from depression
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D79
divisions: D07
divisions: F83
divisions: C08
keywords: Decision-making, Pavlovian-instrumental transfer, emotional reactions, major depressive disorder
note: Copyright © Cambridge University Press 2016 This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: BACKGROUND: Changes in reflexive emotional responses are hallmarks of depression, but how emotional reflexes make an impact on adaptive decision-making in depression has not been examined formally. Using a Pavlovian-instrumental transfer (PIT) task, we compared the influence of affectively valenced stimuli on decision-making in depression and generalized anxiety disorder compared with healthy controls; and related this to the longitudinal course of the illness. METHOD: A total of 40 subjects with a current DSM-IV-TR diagnosis of major depressive disorder, dysthymia, generalized anxiety disorder, or a combination thereof, and 40 matched healthy controls performed a PIT task that assesses how instrumental approach and withdrawal behaviours are influenced by appetitive and aversive Pavlovian conditioned stimuli (CSs). Patients were followed up after 4-6 months. Analyses focused on patients with depression alone (n = 25). RESULTS: In healthy controls, Pavlovian CSs exerted action-specific effects, with appetitive CSs boosting active approach and aversive CSs active withdrawal. This action-specificity was absent in currently depressed subjects. Greater action-specificity in patients was associated with better recovery over the follow-up period. CONCLUSIONS: Depression is associated with an abnormal influence of emotional reactions on decision-making in a way that may predict recovery.
date: 2016-04
date_type: published
official_url: http://dx.doi.org/10.1017/S0033291715002597
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1110006
doi: 10.1017/S0033291715002597
pii: S0033291715002597
language_elements: eng
lyricists_name: Dayan, Peter
lyricists_name: Dolan, Raymond
lyricists_name: Huys, Quentin
lyricists_id: PDAYA65
lyricists_id: RJDOL46
lyricists_id: QHUYS49
actors_name: Barczynska, Patrycja
actors_id: PBARC91
actors_role: owner
full_text_status: public
publication: Psychological Medicine
volume: 46
number: 5
pagerange: 1027-1035
event_location: England
issn: 1469-8978
citation:        Huys, QJ;    Gölzer, M;    Friedel, E;    Heinz, A;    Cools, R;    Dayan, P;    Dolan, RJ;      (2016)    The specificity of Pavlovian regulation is associated with recovery from depression.                   Psychological Medicine , 46  (5)   pp. 1027-1035.    10.1017/S0033291715002597 <https://doi.org/10.1017/S0033291715002597>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1481113/1/S0033291715002597a.pdf