eprintid: 1479390
rev_number: 27
eprint_status: archive
userid: 608
dir: disk0/01/47/93/90
datestamp: 2016-04-16 22:36:57
lastmod: 2021-10-04 01:41:49
status_changed: 2016-06-10 11:27:15
type: article
metadata_visibility: show
creators_name: Bai, J
creators_name: Wang, JT
creators_name: Rubio, N
creators_name: Protti, A
creators_name: Heidari, H
creators_name: Elgogary, R
creators_name: Southern, P
creators_name: Al-Jamal, WT
creators_name: Sosabowski, J
creators_name: Shah, AM
creators_name: Bals, S
creators_name: Pankhurst, QA
creators_name: Al-Jamal, KT
title: Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F42
keywords: PEGylated PLGA, magnetic resonance imaging, magnetic targeting, nuclear imaging, optical imaging
note: Copyright © 2015 Ivyspring International Publisher. This article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (http://creativecommons.org/licenses/by-nc-nd/4.0/) Reproduction is permitted for personal, noncommercial use only, provided that the article is in whole, unmodified, and properly cited.
abstract: Triple-modal imaging magnetic nanocapsules, encapsulating hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intravenous administration in tumour-bearing mice. The engineered magnetic polymeric nanocapsules m-NCs are ~200 nm in size with negative Zeta potential and shown to be spherical in shape. The loading efficiency of superparamagnetic iron oxide nanoparticles in the m-NC was ~100%. Up to ~3- and ~2.2-fold increase in tumour uptake at 1 and 24 h was achieved, when a static magnetic field was applied to the tumour for 1 hour. m-NCs, with multiple imaging probes (e.g. indocyanine green, superparamagnetic iron oxide nanoparticles and indium-111), were capable of triple-modal imaging (fluorescence/magnetic resonance/nuclear imaging) in vivo. Using triple-modal imaging is to overcome the intrinsic limitations of single modality imaging and provides complementary information on the spatial distribution of the nanocarrier within the tumour. The significant findings of this study could open up new research perspectives in using novel magnetically-responsive nanomaterials in magnetic-drug targeting combined with multi-modal imaging.
date: 2016-01-01
date_type: published
official_url: http://dx.doi.org/10.7150/thno.11918
oa_status: green
full_text_type: pub
pmcid: PMC4737722
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1105894
doi: 10.7150/thno.11918
pii: thnov06p0342
lyricists_name: Pankhurst, Quentin
lyricists_name: Southern, Paul
lyricists_id: QAPAN40
lyricists_id: PJDSO74
full_text_status: public
publication: Theranostics
volume: 6
number: 3
pagerange: 342-356
event_location: Australia
issn: 1838-7640
citation:        Bai, J;    Wang, JT;    Rubio, N;    Protti, A;    Heidari, H;    Elgogary, R;    Southern, P;                         ... Al-Jamal, KT; + view all <#>        Bai, J;  Wang, JT;  Rubio, N;  Protti, A;  Heidari, H;  Elgogary, R;  Southern, P;  Al-Jamal, WT;  Sosabowski, J;  Shah, AM;  Bals, S;  Pankhurst, QA;  Al-Jamal, KT;   - view fewer <#>    (2016)    Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo.                   Theranostics , 6  (3)   pp. 342-356.    10.7150/thno.11918 <https://doi.org/10.7150/thno.11918>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1479390/1/Pankhurst_2016%20Theranostics%20Triple-modal%20imaging.pdf