TY  - JOUR
A1  - Bai, J
A1  - Wang, JT
A1  - Rubio, N
A1  - Protti, A
A1  - Heidari, H
A1  - Elgogary, R
A1  - Southern, P
A1  - Al-Jamal, WT
A1  - Sosabowski, J
A1  - Shah, AM
A1  - Bals, S
A1  - Pankhurst, QA
A1  - Al-Jamal, KT
JF  - Theranostics
SN  - 1838-7640
UR  - http://dx.doi.org/10.7150/thno.11918
N1  - Copyright © 2015 Ivyspring International Publisher. This article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (http://creativecommons.org/licenses/by-nc-nd/4.0/) Reproduction is permitted for personal, noncommercial use only, provided that the article is in whole, unmodified, and properly cited.
IS  - 3
SP  - 342
VL  - 6
KW  - PEGylated PLGA
KW  -  magnetic resonance imaging
KW  -  magnetic targeting
KW  -  nuclear imaging
KW  -  optical imaging
ID  - discovery1479390
N2  - Triple-modal imaging magnetic nanocapsules, encapsulating hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intravenous administration in tumour-bearing mice. The engineered magnetic polymeric nanocapsules m-NCs are ~200 nm in size with negative Zeta potential and shown to be spherical in shape. The loading efficiency of superparamagnetic iron oxide nanoparticles in the m-NC was ~100%. Up to ~3- and ~2.2-fold increase in tumour uptake at 1 and 24 h was achieved, when a static magnetic field was applied to the tumour for 1 hour. m-NCs, with multiple imaging probes (e.g. indocyanine green, superparamagnetic iron oxide nanoparticles and indium-111), were capable of triple-modal imaging (fluorescence/magnetic resonance/nuclear imaging) in vivo. Using triple-modal imaging is to overcome the intrinsic limitations of single modality imaging and provides complementary information on the spatial distribution of the nanocarrier within the tumour. The significant findings of this study could open up new research perspectives in using novel magnetically-responsive nanomaterials in magnetic-drug targeting combined with multi-modal imaging.
EP  - 356
AV  - public
Y1  - 2016/01/01/
TI  - Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo
ER  -