eprintid: 1479053
rev_number: 26
eprint_status: archive
userid: 608
dir: disk0/01/47/90/53
datestamp: 2016-04-16 21:48:57
lastmod: 2021-11-01 02:08:24
status_changed: 2018-04-20 15:00:39
type: article
metadata_visibility: show
creators_name: Owen, J
creators_name: Rademeyer, P
creators_name: Chung, D
creators_name: Cheng, Q
creators_name: Holroyd, D
creators_name: Coussios, C
creators_name: Friend, P
creators_name: Pankhurst, QA
creators_name: Stride, E
title: Magnetic targeting of microbubbles against physiologically relevant flow conditions
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F42
keywords: Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, microbubbles, magnetic targeting, ultrasound, drug delivery, contrast agent, imaging, Ultrasound Contrast Agents, Drug-Delivery, Gene Delivery, In-Vitro, Porcine Liver, Cancer, Microspheres, Doxorubicin, Release, Force
note: © 2015 The Authors.
Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
abstract: The localization of microbubbles to a treatment site has been shown to be essential to their effectiveness in therapeutic applications such as targeted drug delivery and gene therapy. A variety of different strategies for achieving localization has been investigated, including biochemical targeting, acoustic radiation force, and the incorporation of superparamagnetic nanoparticles into microbubbles to enable their manipulation using an externally applied magnetic field. The third of these strategies has the advantage of concentrating microbubbles in a target region without exposing them to ultrasound, and can be used in conjunction with biochemical targeting to achieve greater specificity. Magnetic microbubbles have been shown to be effective for therapeutic delivery in vitro and in vivo. Whether this technique can be successfully applied in humans however remains an open question. The aim of this study was to determine the range of flow conditions under which targeting could be achieved. In vitro results indicate that magnetic microbubbles can be retained using clinically acceptable magnetic fields, for both the high shear rates (approx. 104 s−1) found in human arterioles and capillaries, and the high flow rates (approx. 3.5 ml s−1) of human arteries. The potential for human in vivo microbubble retention was further demonstrated using a perfused porcine liver model.
date: 2015-10-06
date_type: published
publisher: ROYAL SOC
official_url: http://dx.doi.org/10.1098/rsfs.2015.0001
oa_status: green
full_text_type: pub
pmcid: PMC4549839
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1067669
doi: 10.1098/rsfs.2015.0001
language_elements: eng
lyricists_name: Pankhurst, Quentin
lyricists_id: QAPAN40
full_text_status: public
publication: Interface Focus
volume: 5
number: 5
article_number: 20150001
pages: 12
event_location: Chicheley, ENGLAND
issn: 2042-8901
citation:        Owen, J;    Rademeyer, P;    Chung, D;    Cheng, Q;    Holroyd, D;    Coussios, C;    Friend, P;         ... Stride, E; + view all <#>        Owen, J;  Rademeyer, P;  Chung, D;  Cheng, Q;  Holroyd, D;  Coussios, C;  Friend, P;  Pankhurst, QA;  Stride, E;   - view fewer <#>    (2015)    Magnetic targeting of microbubbles against physiologically relevant flow conditions.                   Interface Focus , 5  (5)    , Article 20150001.  10.1098/rsfs.2015.0001 <https://doi.org/10.1098/rsfs.2015.0001>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1479053/1/Pankhurst_Magnetic%20targeting%20of%20microbubbles%20against%20physiologically%20relevant%20flow%20conditions.pdf