eprintid: 1478423 rev_number: 62 eprint_status: archive userid: 608 dir: disk0/01/47/84/23 datestamp: 2016-04-16 19:32:28 lastmod: 2021-12-02 23:05:23 status_changed: 2016-11-29 10:13:33 type: article metadata_visibility: show creators_name: Franke, B creators_name: Stein, JL creators_name: Ripke, S creators_name: Anttila, V creators_name: Hibar, DP creators_name: van Hulzen, KJ creators_name: Arias-Vasquez, A creators_name: Smoller, JW creators_name: Nichols, TE creators_name: Neale, MC creators_name: McIntosh, AM creators_name: Lee, P creators_name: McMahon, FJ creators_name: Meyer-Lindenberg, A creators_name: Mattheisen, M creators_name: Andreassen, OA creators_name: Gruber, O creators_name: Sachdev, PS creators_name: Roiz-Santiañez, R creators_name: Saykin, AJ creators_name: Ehrlich, S creators_name: Mather, KA creators_name: Turner, JA creators_name: Schwarz, E creators_name: Thalamuthu, A creators_name: Yao, Y creators_name: Ho, YY creators_name: Martin, NG creators_name: Wright, MJ creators_name: Schizophrenia Working Group of the Psychiatric Genomics Consorti, . creators_name: Psychosis Endophenotypes International Consortium, . creators_name: Wellcome Trust Case Control Consortium 2, . creators_name: Enigma Consortium, . creators_name: O'Donovan, MC creators_name: Thompson, PM creators_name: Neale, BM creators_name: Medland, SE creators_name: Sullivan, PF title: Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D79 divisions: D07 divisions: F81 divisions: F86 divisions: C08 divisions: D09 divisions: F99 divisions: D13 divisions: G23 keywords: Brain, Endophenotypes, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Magnetic Resonance Imaging, Neuroimaging, Organ Size, Polymorphism, Single Nucleotide, Schizophrenia note: © 2016 Nature America, Inc. All rights reserved. abstract: Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. date: 2016-03 date_type: published official_url: http://doi.org/10.1038/nn.4228 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1110109 doi: 10.1038/nn.4228 pii: nn.4228 lyricists_name: Bramon, Elvira lyricists_name: Curtis, David lyricists_name: Hardy, John lyricists_name: McQuillin, Andrew lyricists_name: Ryten, Mina lyricists_name: Sisodiya, Sanjay lyricists_name: Smalley, June lyricists_name: Trabzuni, Daniah lyricists_id: EBRAM47 lyricists_id: DCURT26 lyricists_id: JHARD28 lyricists_id: AMCQU28 lyricists_id: MBARI42 lyricists_id: SMSIS90 lyricists_id: JASMA87 lyricists_id: DTRAB86 full_text_status: public publication: Nature Neuroscience volume: 19 number: 3 pagerange: 420-431 event_location: United States issn: 1546-1726 citation: Franke, B; Stein, JL; Ripke, S; Anttila, V; Hibar, DP; van Hulzen, KJ; Arias-Vasquez, A; ... Sullivan, PF; + view all <#> Franke, B; Stein, JL; Ripke, S; Anttila, V; Hibar, DP; van Hulzen, KJ; Arias-Vasquez, A; Smoller, JW; Nichols, TE; Neale, MC; McIntosh, AM; Lee, P; McMahon, FJ; Meyer-Lindenberg, A; Mattheisen, M; Andreassen, OA; Gruber, O; Sachdev, PS; Roiz-Santiañez, R; Saykin, AJ; Ehrlich, S; Mather, KA; Turner, JA; Schwarz, E; Thalamuthu, A; Yao, Y; Ho, YY; Martin, NG; Wright, MJ; Schizophrenia Working Group of the Psychiatric Genomics Consorti, .; Psychosis Endophenotypes International Consortium, .; Wellcome Trust Case Control Consortium 2, .; Enigma Consortium, .; O'Donovan, MC; Thompson, PM; Neale, BM; Medland, SE; Sullivan, PF; - view fewer <#> (2016) Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nature Neuroscience , 19 (3) pp. 420-431. 10.1038/nn.4228 <https://doi.org/10.1038/nn.4228>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1478423/1/bramon_Genetic%20influences%20on%20schizophrenia%20and%20subcortical%20brain%20volumes%253A%20large-scale%20proof%20of%20concept.pdf