TY  - JOUR
UR  - http://doi.org/10.1038/nn.4228
SN  - 1546-1726
A1  - Franke, B
A1  - Stein, JL
A1  - Ripke, S
A1  - Anttila, V
A1  - Hibar, DP
A1  - van Hulzen, KJ
A1  - Arias-Vasquez, A
A1  - Smoller, JW
A1  - Nichols, TE
A1  - Neale, MC
A1  - McIntosh, AM
A1  - Lee, P
A1  - McMahon, FJ
A1  - Meyer-Lindenberg, A
A1  - Mattheisen, M
A1  - Andreassen, OA
A1  - Gruber, O
A1  - Sachdev, PS
A1  - Roiz-Santiañez, R
A1  - Saykin, AJ
A1  - Ehrlich, S
A1  - Mather, KA
A1  - Turner, JA
A1  - Schwarz, E
A1  - Thalamuthu, A
A1  - Yao, Y
A1  - Ho, YY
A1  - Martin, NG
A1  - Wright, MJ
A1  - Schizophrenia Working Group of the Psychiatric Genomics Consorti, .
A1  - Psychosis Endophenotypes International Consortium, .
A1  - Wellcome Trust Case Control Consortium 2, .
A1  - Enigma Consortium, .
A1  - O'Donovan, MC
A1  - Thompson, PM
A1  - Neale, BM
A1  - Medland, SE
A1  - Sullivan, PF
JF  - Nature Neuroscience
VL  - 19
SP  - 420
IS  - 3
N1  - © 2016 Nature America, Inc. All rights reserved.
N2  - Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.
ID  - discovery1478423
KW  - Brain
KW  -  Endophenotypes
KW  -  Genetic Predisposition to Disease
KW  -  Genome-Wide Association Study
KW  -  Humans
KW  -  Linkage Disequilibrium
KW  -  Magnetic Resonance Imaging
KW  -  Neuroimaging
KW  -  Organ Size
KW  -  Polymorphism
KW  -  Single Nucleotide
KW  -  Schizophrenia
AV  - public
Y1  - 2016/03//
EP  - 431
TI  - Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
ER  -