@article{discovery1478423,
          number = {3},
            year = {2016},
           month = {March},
         journal = {Nature Neuroscience},
           title = {Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept},
            note = {{\copyright} 2016 Nature America, Inc. All rights reserved.},
           pages = {420--431},
          volume = {19},
             url = {http://doi.org/10.1038/nn.4228},
            issn = {1546-1726},
        abstract = {Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.},
        keywords = {Brain, Endophenotypes, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Magnetic Resonance Imaging, Neuroimaging, Organ Size, Polymorphism, Single Nucleotide, Schizophrenia},
          author = {Franke, B and Stein, JL and Ripke, S and Anttila, V and Hibar, DP and van Hulzen, KJ and Arias-Vasquez, A and Smoller, JW and Nichols, TE and Neale, MC and McIntosh, AM and Lee, P and McMahon, FJ and Meyer-Lindenberg, A and Mattheisen, M and Andreassen, OA and Gruber, O and Sachdev, PS and Roiz-Santia{\~n}ez, R and Saykin, AJ and Ehrlich, S and Mather, KA and Turner, JA and Schwarz, E and Thalamuthu, A and Yao, Y and Ho, YY and Martin, NG and Wright, MJ and Schizophrenia Working Group of the Psychiatric Genomics Consorti, . and Psychosis Endophenotypes International Consortium, . and Wellcome Trust Case Control Consortium 2, . and Enigma Consortium, . and O'Donovan, MC and Thompson, PM and Neale, BM and Medland, SE and Sullivan, PF}
}