<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1477078> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/dc/terms/title> "Defining the risk threshold for risk reducing salpingo-oophorectomy for ovarian cancer prevention in low risk postmenopausal women"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/ontology/bibo/abstract> "OBJECTIVE: To define risk thresholds for cost-effectiveness of risk-reducing salpingo-oophorectomy (RRSO) for ovarian cancer (OC) prevention in low/intermediate risk postmenopausal women. METHODS: A decision-analytic model compares lifetime costs-&-effects of offering 'RRSO' with 'no RRSO' to postmenopausal women ≥50years for different lifetime OC-risk thresholds: 2%, 4%, 5%, 6%, 8% and 10%. Well established data from the literature are used to estimate total costs, effects in terms of Quality-Adjusted-Life-Years(QALYs), cancer incidence, incremental cost-effectiveness ratio(ICER) and impact. Costs are reported at 2012 prices; costs/outcomes discounted at 3.5%. Deterministic/probabilistic sensitivity analysis (PSA) evaluate model uncertainty. RESULTS: RRSO does not save QALYs and is not cost-effective at the 2% general population lifetime OC-risk. At 4% OC-risk RRSO saves QALYs but is not cost-effective. At risk thresholds ≥5%, RRSO saves more life-years and QALYs and is highly cost-effective. The ICERs for OC-risk levels 5%, 6%, 8% and 10% are £15,247, £9958, £4584, and £1864 respectively. The gain in life-years from RRSO equates to 29.2, 40.1, 62.1 and 80.3days at risk thresholds of 5%, 6%, 8% and 10% respectively. The results are not sensitive to treatment costs of RRSO/OC/cardiovascular events but are sensitive to utility-scores for RRSO. On PSA, 67%, 80%, 84%, 91% and 94% of simulations at risk thresholds of 4%, 5%, 6%, 8% and 10% respectively are cost-effective for RRSO. CONCLUSION: RRSO is highly cost-effective in postmenopausal women aged >50 with ≥5% lifetime OC-risk and increases life-expectancy by ≥29.2days. The results could have significant clinical implications given the improvements in risk prediction and falling costs of genotyping."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/dc/terms/date> "2015-12" .
<https://discovery.ucl.ac.uk/id/document/199477> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/ontology/bibo/volume> "139" .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/ontology/bibo/issue> "3" .
<https://discovery.ucl.ac.uk/id/publication/ext-10956859> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-10956859> <http://xmlns.com/foaf/0.1/name> "Gynecologic Oncology"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-10956859> .
<https://discovery.ucl.ac.uk/id/publication/ext-10956859> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:10956859> .
<https://discovery.ucl.ac.uk/id/publication/ext-10956859> <http://purl.org/ontology/bibo/issn> "10956859" .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-791b6c2958409eaf21d2b64b40c1fcb0> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1477078#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1477078#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-791b6c2958409eaf21d2b64b40c1fcb0> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-17e14609675cf8426a92926b65a38462> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1477078#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1477078#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-17e14609675cf8426a92926b65a38462> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-caa99d6e77df60ce3981919ed9963ed4> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1477078#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1477078#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-caa99d6e77df60ce3981919ed9963ed4> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8cf7d1c54289c3d6680b7225f6650d55> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1477078#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1477078#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-8cf7d1c54289c3d6680b7225f6650d55> .
<https://discovery.ucl.ac.uk/id/person/ext-caa99d6e77df60ce3981919ed9963ed4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-caa99d6e77df60ce3981919ed9963ed4> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-caa99d6e77df60ce3981919ed9963ed4> <http://xmlns.com/foaf/0.1/familyName> "Pearce"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-caa99d6e77df60ce3981919ed9963ed4> <http://xmlns.com/foaf/0.1/name> "L Pearce"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-791b6c2958409eaf21d2b64b40c1fcb0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-791b6c2958409eaf21d2b64b40c1fcb0> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-791b6c2958409eaf21d2b64b40c1fcb0> <http://xmlns.com/foaf/0.1/familyName> "Manchanda"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-791b6c2958409eaf21d2b64b40c1fcb0> <http://xmlns.com/foaf/0.1/name> "R Manchanda"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-17e14609675cf8426a92926b65a38462> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-17e14609675cf8426a92926b65a38462> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-17e14609675cf8426a92926b65a38462> <http://xmlns.com/foaf/0.1/familyName> "Legood"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-17e14609675cf8426a92926b65a38462> <http://xmlns.com/foaf/0.1/name> "R Legood"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8cf7d1c54289c3d6680b7225f6650d55> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8cf7d1c54289c3d6680b7225f6650d55> <http://xmlns.com/foaf/0.1/givenName> "U"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8cf7d1c54289c3d6680b7225f6650d55> <http://xmlns.com/foaf/0.1/familyName> "Menon"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8cf7d1c54289c3d6680b7225f6650d55> <http://xmlns.com/foaf/0.1/name> "U Menon"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/document/199477> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/199477> <http://www.w3.org/2000/01/rdf-schema#label> "Defining the risk threshold for risk reducing salpingo-oophorectomy for ovarian cancer prevention in low risk postmenopausal women (Text)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://purl.org/dc/elements/1.1/hasVersion> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://eprints.org/ontology/hasAccepted> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/document/199477> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/1477078/1/Revised_GO_POSTmen-RRSO_Threshold_HE_anal_vF5-UNMARKED.pdf> .
<https://discovery.ucl.ac.uk/id/document/199477> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/1477078/1/Revised_GO_POSTmen-RRSO_Threshold_HE_anal_vF5-UNMARKED.pdf> .
<https://discovery.ucl.ac.uk/id/eprint/1477078/1/Revised_GO_POSTmen-RRSO_Threshold_HE_anal_vF5-UNMARKED.pdf> <http://www.w3.org/2000/01/rdf-schema#label> "Revised_GO_POSTmen-RRSO_Threshold_HE_anal_vF5-UNMARKED.pdf"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/199478> .
<https://discovery.ucl.ac.uk/id/document/199478> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/199478> <http://www.w3.org/2000/01/rdf-schema#label> "Defining the risk threshold for risk reducing salpingo-oophorectomy for ovarian cancer prevention in low risk postmenopausal women (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/199478> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/document/199478> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/document/199478> <http://eprints.org/relation/islightboxThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/199479> .
<https://discovery.ucl.ac.uk/id/document/199479> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/199479> <http://www.w3.org/2000/01/rdf-schema#label> "Defining the risk threshold for risk reducing salpingo-oophorectomy for ovarian cancer prevention in low risk postmenopausal women (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/199479> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/document/199479> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/document/199479> <http://eprints.org/relation/ispreviewThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/199480> .
<https://discovery.ucl.ac.uk/id/document/199480> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/199480> <http://www.w3.org/2000/01/rdf-schema#label> "Defining the risk threshold for risk reducing salpingo-oophorectomy for ovarian cancer prevention in low risk postmenopausal women (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/199480> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/document/199480> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/document/199480> <http://eprints.org/relation/ismediumThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/199481> .
<https://discovery.ucl.ac.uk/id/document/199481> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/199481> <http://www.w3.org/2000/01/rdf-schema#label> "Defining the risk threshold for risk reducing salpingo-oophorectomy for ovarian cancer prevention in low risk postmenopausal women (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/199481> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/document/199481> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/document/199481> <http://eprints.org/relation/issmallThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/199482> .
<https://discovery.ucl.ac.uk/id/document/199482> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/199482> <http://www.w3.org/2000/01/rdf-schema#label> "Defining the risk threshold for risk reducing salpingo-oophorectomy for ovarian cancer prevention in low risk postmenopausal women (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/199482> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/document/199482> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/document/199482> <http://eprints.org/relation/isIndexCodesVersionOf> <https://discovery.ucl.ac.uk/id/document/199477> .
<https://discovery.ucl.ac.uk/id/eprint/1477078> <http://www.w3.org/2000/01/rdf-schema#seeAlso> <https://discovery.ucl.ac.uk/id/eprint/1477078/> .
<https://discovery.ucl.ac.uk/id/eprint/1477078/> <http://purl.org/dc/elements/1.1/title> "HTML Summary of #1477078 \n\nDefining the risk threshold for risk reducing salpingo-oophorectomy for ovarian cancer prevention in low risk postmenopausal women\n\n" .
<https://discovery.ucl.ac.uk/id/eprint/1477078/> <http://purl.org/dc/elements/1.1/format> "text/html" .
<https://discovery.ucl.ac.uk/id/eprint/1477078/> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1477078> .