eprintid: 1476571
rev_number: 29
eprint_status: archive
userid: 608
dir: disk0/01/47/65/71
datestamp: 2016-03-15 10:50:31
lastmod: 2021-10-04 01:59:39
status_changed: 2016-03-15 10:50:31
type: article
metadata_visibility: show
creators_name: Bond, RL
creators_name: Downey, LE
creators_name: Weston, PSJ
creators_name: Slattery, CF
creators_name: Clark, CN
creators_name: Macpherson, K
creators_name: Mummery, CJ
creators_name: Warren, JD
title: Processing of Self versus Non-Self in Alzheimer's Disease
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
keywords: Alzheimer's, self processing, voice, source memory, Interpersonal Reactivity Index, tactile
note: Copyright © 2016 Bond, Downey, Weston, Slattery, Clark, Macpherson, Mummery and Warren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
abstract: Despite considerable evidence for abnormalities of self-awareness in Alzheimer’s disease (AD), the cognitive mechanisms of altered self-processing in AD have not been fully defined. Here we addressed this issue in a detailed analysis of self/non-self-processing in three patients with AD. We designed a novel neuropsychological battery comprising tests of tactile body schema coding, attribution of tactile events to self versus external agents, and memory for self- versus non-self-generated vocal information, administered in conjunction with a daily life measure of self/non-self-processing (the Interpersonal Reactivity Index). Three male AD patients (aged 54–68 years; one with a pathogenic mutation in the Presenilin 1 gene, one with a pathogenic mutation in the Amyloid Precursor Protein gene, and one with a CSF protein profile supporting underlying AD pathology) were studied in relation to a group of eight healthy older male individuals (aged 58–74 years). Compared to healthy controls, all patients had relatively intact tactile body schema processing. In contrast, all patients showed impaired memory for words previously presented using the patient’s own voice whereas memory for words presented in other voices was less consistently affected. Two patients showed increased levels of emotional contagion and reduced perspective taking on the Interpersonal Reactivity Index. Our findings suggest that AD may be associated with deficient self/non-self differentiation over time despite a relatively intact body image: this profile of altered self-processing contrasts with the deficit of tactile body schema previously described in frontotemporal dementia associated with C9orf72 mutations. We present these findings as a preliminary rationale to direct future systematic study in larger patient cohorts.
date: 2016-03-08
publisher: Frontiers Research Foundation
official_url: http://dx.doi.org/10.3389/fnhum.2016.00097
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1118514
doi: 10.3389/fnhum.2016.00097
lyricists_name: Bond, Rebecca
lyricists_name: Clark, Camilla
lyricists_name: Lu, Kirsty
lyricists_name: Mummery, Catherine
lyricists_name: Slattery, Catherine
lyricists_name: Warren, Jason
lyricists_name: Weston, Philip
lyricists_id: RLBON31
lyricists_id: CNCLA37
lyricists_id: KMACP41
lyricists_id: CJMUM93
lyricists_id: CSLAT87
lyricists_id: JDWAR75
lyricists_id: PWEST19
actors_name: Bond, Rebecca
actors_id: RLBON31
actors_role: owner
full_text_status: public
publication: Frontiers in Human Neuroscience
volume: 10
article_number: 97
issn: 1662-5161
citation:        Bond, RL;    Downey, LE;    Weston, PSJ;    Slattery, CF;    Clark, CN;    Macpherson, K;    Mummery, CJ;           Bond, RL;  Downey, LE;  Weston, PSJ;  Slattery, CF;  Clark, CN;  Macpherson, K;  Mummery, CJ;  Warren, JD;   - view fewer <#>    (2016)    Processing of Self versus Non-Self in Alzheimer's Disease.                   Frontiers in Human Neuroscience , 10     , Article 97.  10.3389/fnhum.2016.00097 <https://doi.org/10.3389/fnhum.2016.00097>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1476571/1/Bond_fnhum-10-00097.pdf