eprintid: 1476230
rev_number: 17
eprint_status: archive
userid: 608
dir: disk0/01/47/62/30
datestamp: 2016-05-06 07:16:21
lastmod: 2019-10-17 09:24:32
status_changed: 2016-05-06 07:16:21
type: thesis
metadata_visibility: show
creators_name: Bem, MA
title: Towards an understanding of the molecular dynamic causes of resistance in the HIV-1 Integrase
ispublished: unpub
divisions: A01
divisions: B04
divisions: C06
divisions: F56
abstract: This work endeavours to explain molecular dynamic causes of resistance in Human Immunodeficiency Virus (HIV) Integrase through simulation of Prototype Foamy Virus (PFV) Intergrase interaction with DNA in the presence of Raltegravir (RLT) for the purpose of efficient and automatic drug ranking of Integrase inhibitors. Chapter One introduces the problem of Acquired Immunodeficiency Syndrome (AIDS) through both historical perspective and current situation by some crude analysis of geographical and social distribution. Similarly HIV is introduced both as a biological species and biochemical system with particular focus on Integrase, one of its essential protein enzymes. Chapter Two contains methods of Molecular Dynamics which are used extensively throughout this thesis (Chapters Four to Six), as well as some scientific background to those methods. Chapter Three describes efforts towards generating viable structure of HIV Integrase intasome for the purpose of Molecular Dynamic analyses. Methods of homology modelling are employed using known homologues of HIV Integrase as input data. The remaining parts of this thesis are made up of three experimental chapters describing Molecular Dynamic simulations of several biochemical systems and their analyses.
date: 2016-04-28
date_type: published
oa_status: green
full_text_type: other
thesis_class: doctoral_open
thesis_view: UCL_Thesis
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1116765
language_elements: English
lyricists_name: Bem, Milo
lyricists_id: MCWIO86
actors_name: Bem, Milo
actors_name: Mackay, Naomi
actors_id: MCWIO86
actors_id: NSDMA44
actors_role: owner
actors_role: impersonator
full_text_status: public
pages: 119
event_title: UCL (University College London)
institution: UCL (University College London)
department: Chemistry
thesis_type: Doctoral
citation:        Bem, MA;      (2016)    Towards an understanding of the molecular dynamic causes of resistance in the HIV-1 Integrase.                   Doctoral thesis , UCL (University College London).     Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1476230/1/Bem_Milo-20160221.pdf