TY  - JOUR
SN  - 1638-6183
UR  - http://dx.doi.org/10.1016/j.biochi.2015.08.004
ID  - discovery1474732
N2  - This article presents a historical review of the protein structure classification database CATH. Together with the SCOP database, CATH remains comprehensive and reasonably up-to-date with the now more than 100,000 protein structures in the PDB. We review the expansion of the CATH and SCOP resources to capture predicted domain structures in the genome sequence data and to provide information on the likely functions of proteins mediated by their constituent domains. The establishment of comprehensive function annotation resources has also meant that domain families can be functionally annotated allowing insights into functional divergence and evolution within protein families.
KW  - Protein structure
KW  -  Structure classification
A1  - Sillitoe, I
A1  - Dawson, N
A1  - Thornton, J
A1  - Orengo, C
JF  - Biochimie
EP  - 217
SP  - 209
AV  - public
VL  - 119
Y1  - 2015/12/01/
TI  - The history of the CATH structural classification of protein domains
N1  - © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/).
ER  -