@article{discovery1474039, title = {A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine}, year = {2015}, journal = {Organic and Biomolecular Chemistry}, month = {August}, number = {29}, pages = {7946--7949}, volume = {13}, note = {This journal is {\copyright} The Royal Society of Chemistry 2015. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.}, author = {Smith, ME and Caspersen, MB and Robinson, E and Morais, M and Maruani, A and Nunes, JP and Nicholls, K and Saxton, MJ and Caddick, S and Baker, JR and Chudasama, V}, issn = {1477-0539}, abstract = {Herein we report the use of bromomaleimides for the construction of stable albumin conjugates via conjugation to its native, single accessible, cysteine followed by hydrolysis. Advantages over the classical maleimide approach are highlighted in terms of quantitative hydrolysis and absence of undesirable retro-Michael deconjugation.}, url = {http://dx.doi.org/10.1039/c5ob01205h} }