eprintid: 1473397 rev_number: 22 eprint_status: archive userid: 608 dir: disk0/01/47/33/97 datestamp: 2015-12-18 12:46:53 lastmod: 2021-09-19 23:37:44 status_changed: 2015-12-18 12:46:53 type: article metadata_visibility: show creators_name: Hope, TM creators_name: Seghier, ML creators_name: Prejawa, S creators_name: Leff, AP creators_name: Price, CJ title: Distinguishing the effect of lesion load from tract disconnection in the arcuate and uncinate fasciculi ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F82 divisions: F83 keywords: Language, MRI, Outcomes, Stroke, White matter note: © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). abstract: Brain imaging studies of functional outcomes after white matter damage have quantified the severity of white matter damage in different ways. Here we compared how the outcome of such studies depends on two different types of measurements: the proportion of the target tract that has been destroyed ('lesion load') and tract disconnection. We demonstrate that conclusions from analyses based on two examples of these measures diverge and that conclusions based solely on lesion load may be misleading. First, we reproduce a recent lesion-load-only analysis which suggests that damage to the arcuate fasciculus, and not to the uncinate fasciculus, is significantly associated with deficits in fluency and naming skills. Next, we repeat the analysis after replacing the measures of lesion load with measures of tract disconnection for both tracts, and observe significant associations between both tracts and both language skills: i.e. the change increases the apparent relevance of the uncinate fasciculus to fluency and naming skills. Finally we show that, in this dataset, disconnection data explains significant variance in both language skills that is not accounted for by lesion load or volume, but lesion load data explains no unique variance in those skills, once disconnection and lesion volume are taken into account. date: 2015-09-21 date_type: published official_url: http://dx.doi.org/10.1016/j.neuroimage.2015.09.025 oa_status: green full_text_type: pub primo: open primo_central: open_green article_type_text: JOURNAL ARTICLE verified: verified_manual elements_id: 1057315 doi: 10.1016/j.neuroimage.2015.09.025 pii: S1053-8119(15)00831-9 language_elements: ENG lyricists_name: Hope, Thomas lyricists_name: Leff, Alexander lyricists_name: Prejawa, Susan lyricists_name: Price, Catherine lyricists_id: THOPE20 lyricists_id: APLEF35 lyricists_id: SPREJ01 lyricists_id: CJPRI95 actors_name: Poirier, Elizabeth actors_id: EPPOI23 actors_role: owner full_text_status: public publication: Neuroimage volume: 125 pagerange: 1169-1173 issn: 1095-9572 citation: Hope, TM; Seghier, ML; Prejawa, S; Leff, AP; Price, CJ; (2015) Distinguishing the effect of lesion load from tract disconnection in the arcuate and uncinate fasciculi. Neuroimage , 125 pp. 1169-1173. 10.1016/j.neuroimage.2015.09.025 <https://doi.org/10.1016/j.neuroimage.2015.09.025>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1473397/1/1-s2.0-S1053811915008319-main.pdf