eprintid: 1473397
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/01/47/33/97
datestamp: 2015-12-18 12:46:53
lastmod: 2021-09-19 23:37:44
status_changed: 2015-12-18 12:46:53
type: article
metadata_visibility: show
creators_name: Hope, TM
creators_name: Seghier, ML
creators_name: Prejawa, S
creators_name: Leff, AP
creators_name: Price, CJ
title: Distinguishing the effect of lesion load from tract disconnection in the arcuate and uncinate fasciculi
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F82
divisions: F83
keywords: Language, MRI, Outcomes, Stroke, White matter
note: © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/).
abstract: Brain imaging studies of functional outcomes after white matter damage have quantified the severity of white matter damage in different ways. Here we compared how the outcome of such studies depends on two different types of measurements: the proportion of the target tract that has been destroyed ('lesion load') and tract disconnection. We demonstrate that conclusions from analyses based on two examples of these measures diverge and that conclusions based solely on lesion load may be misleading. First, we reproduce a recent lesion-load-only analysis which suggests that damage to the arcuate fasciculus, and not to the uncinate fasciculus, is significantly associated with deficits in fluency and naming skills. Next, we repeat the analysis after replacing the measures of lesion load with measures of tract disconnection for both tracts, and observe significant associations between both tracts and both language skills: i.e. the change increases the apparent relevance of the uncinate fasciculus to fluency and naming skills. Finally we show that, in this dataset, disconnection data explains significant variance in both language skills that is not accounted for by lesion load or volume, but lesion load data explains no unique variance in those skills, once disconnection and lesion volume are taken into account.
date: 2015-09-21
date_type: published
official_url: http://dx.doi.org/10.1016/j.neuroimage.2015.09.025
oa_status: green
full_text_type: pub
primo: open
primo_central: open_green
article_type_text: JOURNAL ARTICLE
verified: verified_manual
elements_id: 1057315
doi: 10.1016/j.neuroimage.2015.09.025
pii: S1053-8119(15)00831-9
language_elements: ENG
lyricists_name: Hope, Thomas
lyricists_name: Leff, Alexander
lyricists_name: Prejawa, Susan
lyricists_name: Price, Catherine
lyricists_id: THOPE20
lyricists_id: APLEF35
lyricists_id: SPREJ01
lyricists_id: CJPRI95
actors_name: Poirier, Elizabeth
actors_id: EPPOI23
actors_role: owner
full_text_status: public
publication: Neuroimage
volume: 125
pagerange: 1169-1173
issn: 1095-9572
citation:        Hope, TM;    Seghier, ML;    Prejawa, S;    Leff, AP;    Price, CJ;      (2015)    Distinguishing the effect of lesion load from tract disconnection in the arcuate and uncinate fasciculi.                   Neuroimage , 125    pp. 1169-1173.    10.1016/j.neuroimage.2015.09.025 <https://doi.org/10.1016/j.neuroimage.2015.09.025>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1473397/1/1-s2.0-S1053811915008319-main.pdf