eprintid: 1473083 rev_number: 22 eprint_status: archive userid: 608 dir: disk0/01/47/30/83 datestamp: 2015-12-08 12:21:16 lastmod: 2021-10-04 01:23:32 status_changed: 2015-12-08 12:21:16 type: article metadata_visibility: show creators_name: Downey, LE creators_name: Mahoney, CJ creators_name: Buckley, AH creators_name: Golden, HL creators_name: Henley, SM creators_name: Schmitz, N creators_name: Schott, JM creators_name: Simpson, IJ creators_name: Ourselin, S creators_name: Fox, NC creators_name: Crutch, SJ creators_name: Warren, JD title: White matter tract signatures of impaired social cognition in frontotemporal lobar degeneration ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F86 divisions: B04 divisions: C05 divisions: F42 keywords: Diffusion tensor imaging, Emotion, Frontotemporal dementia, Sarcasm, Social cognition, Voxel based morphometry note: © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). abstract: Impairments of social cognition are often leading features in frontotemporal lobar degeneration (FTLD) and likely to reflect large-scale brain network disintegration. However, the neuroanatomical basis of impaired social cognition in FTLD and the role of white matter connections have not been defined. Here we assessed social cognition in a cohort of patients representing two core syndromes of FTLD, behavioural variant frontotemporal dementia (bvFTD; n = 29) and semantic variant primary progressive aphasia (svPPA; n = 15), relative to healthy older individuals (n = 37) using two components of the Awareness of Social Inference Test, canonical emotion identification and sarcasm identification. Diffusion tensor imaging (DTI) was used to derive white matter tract correlates of social cognition performance and compared with the distribution of grey matter atrophy on voxel-based morphometry. The bvFTD and svPPA groups showed comparably severe deficits for identification of canonical emotions and sarcasm, and these deficits were correlated with distributed and overlapping white matter tract alterations particularly affecting frontotemporal connections in the right cerebral hemisphere. The most robust DTI associations were identified in white matter tracts linking cognitive and evaluative processing with emotional responses: anterior thalamic radiation, fornix (emotion identification) and uncinate fasciculus (sarcasm identification). DTI associations of impaired social cognition were more consistent than corresponding grey matter associations. These findings delineate a brain network substrate for the social impairment that characterises FTLD syndromes. The findings further suggest that DTI can generate sensitive and functionally relevant indexes of white matter damage in FTLD, with potential to transcend conventional syndrome boundaries. date: 2015-06-23 date_type: published official_url: http://dx.doi.org/10.1016/j.nicl.2015.06.005 oa_status: green full_text_type: pub pmcid: PMC4513187 language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1044076 doi: 10.1016/j.nicl.2015.06.005 pii: S2213-1582(15)00111-4 language_elements: eng lyricists_name: Crutch, Sebastian lyricists_name: Fox, Nicholas lyricists_name: Golden, Hannah lyricists_name: Henley, Susie lyricists_name: Mahoney, Colin lyricists_name: Ourselin, Sebastien lyricists_name: Schott, Jonathan lyricists_name: Warren, Jason lyricists_id: SJCRU02 lyricists_id: NCIFO25 lyricists_id: HLGOL19 lyricists_id: SHENL31 lyricists_id: CJMAH85 lyricists_id: SOURS59 lyricists_id: JMSCH12 lyricists_id: JDWAR75 actors_name: Barczynska, Patrycja actors_id: PBARC91 actors_role: owner full_text_status: public publication: Neuroimage Clinical volume: 8 pagerange: 640-651 event_location: Netherlands issn: 2213-1582 citation: Downey, LE; Mahoney, CJ; Buckley, AH; Golden, HL; Henley, SM; Schmitz, N; Schott, JM; ... Warren, JD; + view all <#> Downey, LE; Mahoney, CJ; Buckley, AH; Golden, HL; Henley, SM; Schmitz, N; Schott, JM; Simpson, IJ; Ourselin, S; Fox, NC; Crutch, SJ; Warren, JD; - view fewer <#> (2015) White matter tract signatures of impaired social cognition in frontotemporal lobar degeneration. Neuroimage Clinical , 8 pp. 640-651. 10.1016/j.nicl.2015.06.005 <https://doi.org/10.1016/j.nicl.2015.06.005>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1473083/1/White%20matter%20tract%20signatures%20of%20impaired%20social%20cognition%20in%20frontotemporal%20lobar%20degeneration.pdf