eprintid: 1473083
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/01/47/30/83
datestamp: 2015-12-08 12:21:16
lastmod: 2021-10-04 01:23:32
status_changed: 2015-12-08 12:21:16
type: article
metadata_visibility: show
creators_name: Downey, LE
creators_name: Mahoney, CJ
creators_name: Buckley, AH
creators_name: Golden, HL
creators_name: Henley, SM
creators_name: Schmitz, N
creators_name: Schott, JM
creators_name: Simpson, IJ
creators_name: Ourselin, S
creators_name: Fox, NC
creators_name: Crutch, SJ
creators_name: Warren, JD
title: White matter tract signatures of impaired social cognition in frontotemporal lobar degeneration
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
divisions: B04
divisions: C05
divisions: F42
keywords: Diffusion tensor imaging, Emotion, Frontotemporal dementia, Sarcasm, Social cognition, Voxel based morphometry
note: © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/).
abstract: Impairments of social cognition are often leading features in frontotemporal lobar degeneration (FTLD) and likely to reflect large-scale brain network disintegration. However, the neuroanatomical basis of impaired social cognition in FTLD and the role of white matter connections have not been defined. Here we assessed social cognition in a cohort of patients representing two core syndromes of FTLD, behavioural variant frontotemporal dementia (bvFTD; n = 29) and semantic variant primary progressive aphasia (svPPA; n = 15), relative to healthy older individuals (n = 37) using two components of the Awareness of Social Inference Test, canonical emotion identification and sarcasm identification. Diffusion tensor imaging (DTI) was used to derive white matter tract correlates of social cognition performance and compared with the distribution of grey matter atrophy on voxel-based morphometry. The bvFTD and svPPA groups showed comparably severe deficits for identification of canonical emotions and sarcasm, and these deficits were correlated with distributed and overlapping white matter tract alterations particularly affecting frontotemporal connections in the right cerebral hemisphere. The most robust DTI associations were identified in white matter tracts linking cognitive and evaluative processing with emotional responses: anterior thalamic radiation, fornix (emotion identification) and uncinate fasciculus (sarcasm identification). DTI associations of impaired social cognition were more consistent than corresponding grey matter associations. These findings delineate a brain network substrate for the social impairment that characterises FTLD syndromes. The findings further suggest that DTI can generate sensitive and functionally relevant indexes of white matter damage in FTLD, with potential to transcend conventional syndrome boundaries.
date: 2015-06-23
date_type: published
official_url: http://dx.doi.org/10.1016/j.nicl.2015.06.005
oa_status: green
full_text_type: pub
pmcid: PMC4513187
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1044076
doi: 10.1016/j.nicl.2015.06.005
pii: S2213-1582(15)00111-4
language_elements: eng
lyricists_name: Crutch, Sebastian
lyricists_name: Fox, Nicholas
lyricists_name: Golden, Hannah
lyricists_name: Henley, Susie
lyricists_name: Mahoney, Colin
lyricists_name: Ourselin, Sebastien
lyricists_name: Schott, Jonathan
lyricists_name: Warren, Jason
lyricists_id: SJCRU02
lyricists_id: NCIFO25
lyricists_id: HLGOL19
lyricists_id: SHENL31
lyricists_id: CJMAH85
lyricists_id: SOURS59
lyricists_id: JMSCH12
lyricists_id: JDWAR75
actors_name: Barczynska, Patrycja
actors_id: PBARC91
actors_role: owner
full_text_status: public
publication: Neuroimage Clinical
volume: 8
pagerange: 640-651
event_location: Netherlands
issn: 2213-1582
citation:        Downey, LE;    Mahoney, CJ;    Buckley, AH;    Golden, HL;    Henley, SM;    Schmitz, N;    Schott, JM;                     ... Warren, JD; + view all <#>        Downey, LE;  Mahoney, CJ;  Buckley, AH;  Golden, HL;  Henley, SM;  Schmitz, N;  Schott, JM;  Simpson, IJ;  Ourselin, S;  Fox, NC;  Crutch, SJ;  Warren, JD;   - view fewer <#>    (2015)    White matter tract signatures of impaired social cognition in frontotemporal lobar degeneration.                   Neuroimage Clinical , 8    pp. 640-651.    10.1016/j.nicl.2015.06.005 <https://doi.org/10.1016/j.nicl.2015.06.005>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1473083/1/White%20matter%20tract%20signatures%20of%20impaired%20social%20cognition%20in%20frontotemporal%20lobar%20degeneration.pdf