eprintid: 1472971 rev_number: 43 eprint_status: archive userid: 608 dir: disk0/01/47/29/71 datestamp: 2016-03-23 15:26:29 lastmod: 2021-12-06 00:58:14 status_changed: 2017-03-23 10:15:35 type: article metadata_visibility: show creators_name: Carnaghan, H creators_name: Baud, D creators_name: Lapidus-Krol, E creators_name: Ryan, G creators_name: Shah, PS creators_name: Pierro, A creators_name: Eaton, S title: Effect of gestational age at birth on neonatal outcomes in gastroschisis ispublished: pub divisions: UCL divisions: B02 divisions: D13 divisions: G22 keywords: Enteral feeding, Gastroschisis, Gestational age, Neonatal outcome, Postnatal outcome, Preterm delivery note: Copyright © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). abstract: INTRODUCTION: Induced birth of fetuses with gastroschisis from 34weeks gestational age (GA) has been proposed to reduce bowel damage. We aimed to determine the effect of birth timing on time to full enteral feeds (ENT), length of hospital stay (LOS), and sepsis. METHODS: A retrospective analysis (2000-2014) of gastroschisis born at ≥34weeks GA was performed. Associations between birth timing and outcomes were analyzed by Mann-Whitney test, Cox regression, and Fisher's exact test. RESULTS: 217 patients were analyzed. Although there was no difference in ENT between those born at 34-36+6weeks GA (median 28 range [6-639] days) compared with ≥37weeks GA (27 [8-349] days) when analyzed by Mann-Whitney test (p=0.5), Cox regression analysis revealed that lower birth GA significantly prolonged ENT (p=0.001). LOS was significantly longer in those born at 34-36+6weeks GA (42 [8-346] days) compared with ≥37weeks GA 34 [11-349] days by both Mann-Whitney (p=0.02) and Cox regression analysis (p<0.0005). Incidence of sepsis was higher in infants born at 34-36+6weeks (32%) vs. infants born at ≥37weeks (17%; p=0.02). CONCLUSIONS: Early birth of fetuses with gastroschisis was associated with delay in reaching full enteral feeds, prolonged hospitalization, and a higher incidence of sepsis. date: 2016-05 official_url: http://dx.doi.org/10.1016/j.jpedsurg.2016.02.013 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1092417 doi: 10.1016/j.jpedsurg.2016.02.013 pii: S0022-3468(16)00076-2 lyricists_name: Carnaghan, Helen lyricists_name: Eaton, Simon lyricists_name: Pierro, Agostino lyricists_id: HCARN88 lyricists_id: SEATO65 lyricists_id: APIER04 actors_name: Eaton, Simon actors_id: SEATO65 actors_role: owner full_text_status: public publication: Journal of Pediatric Surgery volume: 51 number: 5 pagerange: 734-738 issn: 1531-5037 citation: Carnaghan, H; Baud, D; Lapidus-Krol, E; Ryan, G; Shah, PS; Pierro, A; Eaton, S; (2016) Effect of gestational age at birth on neonatal outcomes in gastroschisis. Journal of Pediatric Surgery , 51 (5) pp. 734-738. 10.1016/j.jpedsurg.2016.02.013 <https://doi.org/10.1016/j.jpedsurg.2016.02.013>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1472971/7/Carnaghan_1-s2.0-S0022346816000762-main.pdf