TY - JOUR IS - 5 KW - Enteral feeding KW - Gastroschisis KW - Gestational age KW - Neonatal outcome KW - Postnatal outcome KW - Preterm delivery A1 - Carnaghan, H A1 - Baud, D A1 - Lapidus-Krol, E A1 - Ryan, G A1 - Shah, PS A1 - Pierro, A A1 - Eaton, S EP - 738 VL - 51 Y1 - 2016/05// TI - Effect of gestational age at birth on neonatal outcomes in gastroschisis AV - public N2 - INTRODUCTION: Induced birth of fetuses with gastroschisis from 34weeks gestational age (GA) has been proposed to reduce bowel damage. We aimed to determine the effect of birth timing on time to full enteral feeds (ENT), length of hospital stay (LOS), and sepsis. METHODS: A retrospective analysis (2000-2014) of gastroschisis born at ?34weeks GA was performed. Associations between birth timing and outcomes were analyzed by Mann-Whitney test, Cox regression, and Fisher's exact test. RESULTS: 217 patients were analyzed. Although there was no difference in ENT between those born at 34-36+6weeks GA (median 28 range [6-639] days) compared with ?37weeks GA (27 [8-349] days) when analyzed by Mann-Whitney test (p=0.5), Cox regression analysis revealed that lower birth GA significantly prolonged ENT (p=0.001). LOS was significantly longer in those born at 34-36+6weeks GA (42 [8-346] days) compared with ?37weeks GA 34 [11-349] days by both Mann-Whitney (p=0.02) and Cox regression analysis (p<0.0005). Incidence of sepsis was higher in infants born at 34-36+6weeks (32%) vs. infants born at ?37weeks (17%; p=0.02). CONCLUSIONS: Early birth of fetuses with gastroschisis was associated with delay in reaching full enteral feeds, prolonged hospitalization, and a higher incidence of sepsis. SN - 1531-5037 SP - 734 JF - Journal of Pediatric Surgery UR - http://dx.doi.org/10.1016/j.jpedsurg.2016.02.013 ID - discovery1472971 N1 - Copyright © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). ER -