eprintid: 1472713
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/01/47/27/13
datestamp: 2015-11-19 16:05:12
lastmod: 2021-09-19 23:27:40
status_changed: 2015-11-19 16:05:12
type: article
metadata_visibility: show
creators_name: Le Duigou, C
creators_name: Savary, E
creators_name: Kullmann, DM
creators_name: Miles, R
title: Induction of Anti-Hebbian LTP in CA1 Stratum Oriens Interneurons: Interactions between Group I Metabotropic Glutamate Receptors and M1 Muscarinic Receptors
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F81
keywords: LTP, hippocampus, interneuron, metabotropic glutamate receptors, muscarinic receptors
note: Copyright © 2015 Le Duigou et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed
abstract: An anti-Hebbian form of LTP is observed at excitatory synapses made with some hippocampal interneurons. LTP induction is facilitated when postsynaptic interneurons are hyperpolarized, presumably because Ca(2+) entry through Ca(2+)-permeable glutamate receptors is enhanced. The contribution of modulatory transmitters to anti-Hebbian LTP induction remains to be established. Activation of group I metabotropic receptors (mGluRs) is required for anti-Hebbian LTP induction in interneurons with cell bodies in the CA1 stratum oriens. This region receives a strong cholinergic innervation from the septum, and muscarinic acetylcholine receptors (mAChRs) share some signaling pathways and cooperate with mGluRs in the control of neuronal excitability.We therefore examined possible interactions between group I mGluRs and mAChRs in anti-Hebbian LTP at synapses which excite oriens interneurons in rat brain slices. We found that blockade of either group I mGluRs or M1 mAChRs prevented the induction of anti-Hebbian LTP by pairing presynaptic activity with postsynaptic hyperpolarization. Blocking either receptor also suppressed long-term effects of activation of the other G-protein coupled receptor on interneuron membrane potential. However, no crossed blockade was detected for mGluR or mAchR effects on interneuron after-burst potentials or on the frequency of miniature EPSPs. Paired recordings between pyramidal neurons and oriens interneurons were obtained to determine whether LTP could be induced without concurrent stimulation of cholinergic axons. Exogenous activation of mAChRs led to LTP, with changes in EPSP amplitude distributions consistent with a presynaptic locus of expression. LTP, however, required noninvasive presynaptic and postsynaptic recordings.
date: 2015-10-07
date_type: published
official_url: http:/d/x.doi.org/10.1523/JNEUROSCI.0956-15.2015
oa_status: green
full_text_type: pub
pmcid: PMC4595614
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1067770
doi: 10.1523/JNEUROSCI.0956-15.2015
pii: 35/40/13542
language_elements: eng
lyricists_name: Kullmann, Dimitri
lyricists_id: DMKUL63
actors_name: Kullmann, Dimitri
actors_name: Barczynska, Patrycja
actors_id: DMKUL63
actors_id: PBARC91
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Journal of Neuroscience
volume: 35
number: 40
pagerange: 13542-13554
event_location: United States
issn: 1529-2401
citation:        Le Duigou, C;    Savary, E;    Kullmann, DM;    Miles, R;      (2015)    Induction of Anti-Hebbian LTP in CA1 Stratum Oriens Interneurons: Interactions between Group I Metabotropic Glutamate Receptors and M1 Muscarinic Receptors.                   Journal of Neuroscience , 35  (40)   pp. 13542-13554.    10.1523/JNEUROSCI.0956-15.2015 <https://doi.org/10.1523/JNEUROSCI.0956-15.2015>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1472713/1/13542.full.pdf