@article{discovery1472457, year = {2015}, volume = {16}, month = {June}, journal = {BMC Bioinformatics}, title = {Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism}, note = {{\copyright} 2015 Patel et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.}, issn = {1471-2105}, keywords = {Animals, Autistic Disorder, Cell Adhesion Molecules, Neuronal, Cell Physiological Phenomena, Gene Ontology, Genome, Genomics, High-Throughput Nucleotide Sequencing, Humans, Membrane Potentials, Mice, Models, Molecular, Nerve Tissue Proteins, Phenotype, Rats, Social Behavior, Synapses, Synaptic Potentials}, abstract = {People with an autistic spectrum disorder (ASD) display a variety of characteristic behavioral traits, including impaired social interaction, communication difficulties and repetitive behavior. This complex neurodevelopment disorder is known to be associated with a combination of genetic and environmental factors. Neurexins and neuroligins play a key role in synaptogenesis and neurexin-neuroligin adhesion is one of several processes that have been implicated in autism spectrum disorders.}, author = {Patel, S and Roncaglia, P and Lovering, RC}, url = {http://dx.doi.org/10.1186/s12859-015-0622-0} }