eprintid: 1472451
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/01/47/24/51
datestamp: 2015-11-11 14:58:35
lastmod: 2021-09-19 22:32:24
status_changed: 2015-11-11 14:58:35
type: article
metadata_visibility: show
creators_name: Ugorji, CO
creators_name: Samson, RS
creators_name: Liechti, MD
creators_name: Panicker, JN
creators_name: Miller, DH
creators_name: Wheeler-Kingshott, CA
creators_name: Yiannakas, MC
title: Grey and White Matter Magnetisation Transfer Ratio Measurements in the Lumbosacral Enlargement: A Pilot In Vivo Study at 3T
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F85
divisions: F87
note: © 2015 Ugorji et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
abstract: Magnetisation transfer (MT) imaging of the central nervous system has provided further insight into the pathophysiology of neurological disease. However, the use of this method to study the lower spinal cord has been technically challenging, despite the important role of this region, not only for motor control of the lower limbs, but also for the neural control of lower urinary tract, sexual and bowel functions. In this study, the feasibility of obtaining reliable grey matter (GM) and white matter (WM) magnetisation transfer ratio (MTR) measurements within the lumbosacral enlargement (LSE) was investigated in ten healthy volunteers using a clinical 3T MRI system. The mean cross-sectional area of the LSE (LSE-CSA) and the mean GM area (LSE-GM-CSA) were first obtained by means of image segmentation and tissue-specific (i.e. WM and GM) MTR measurements within the LSE were subsequently obtained. The reproducibility of the segmentation method and MTR measurements was assessed from repeated measurements and their % coefficient of variation (%COV). Mean (± SD) LSE-CSA across 10 healthy subjects was 59.3 (± 8.4) mm2 and LSE-GM-CSA was 17.0 (± 3.1) mm2. The mean intra- and inter-rater % COV for measuring the LSE-CSA were 0.8% and 2.3%, respectively and for the LSE-GM-CSA were 3.8% and 5.4%, respectively. Mean (± SD) WM-MTR was 43.2 (± 4.4) and GM-MTR was 40.9 (± 4.3). The mean scan-rescan % COV for measuring WM-MTR was 4.6% and for GM-MTR was 3.8%. Using a paired t-test, a statistically significant difference was identified between WM-MTR and GM-MTR in the LSE (p<0.0001). This pilot study has shown that it is possible to obtain reliable tissue-specific MTR measurements within the LSE using a clinical MR system at 3T. The MTR acquisition and analysis protocol presented in this study can be used in future investigations of intrinsic spinal cord diseases that affect the LSE.
date: 2015-07-31
date_type: published
official_url: http://dx.doi.org/10.1371/journal.pone.0134495
oa_status: green
full_text_type: pub
pmcid: PMC4521783
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1045281
doi: 10.1371/journal.pone.0134495
pii: PONE-D-15-13788
language_elements: eng
lyricists_name: Miller, David
lyricists_name: Panicker, Jalesh
lyricists_name: Samson, Rebecca
lyricists_name: Wheeler-Kingshott, Claudia
lyricists_name: Yiannakas, Marios
lyricists_id: DHMIL08
lyricists_id: JPANI24
lyricists_id: RSSAM62
lyricists_id: CWHEE14
lyricists_id: MYIAN77
actors_name: Panicker, Jalesh
actors_name: Gibson, Alice
actors_id: JPANI24
actors_id: AGIBS47
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: PLoS One
volume: 10
number: 7
article_number: e0134495
event_location: United States
issn: 1932-6203
citation:        Ugorji, CO;    Samson, RS;    Liechti, MD;    Panicker, JN;    Miller, DH;    Wheeler-Kingshott, CA;    Yiannakas, MC;      (2015)    Grey and White Matter Magnetisation Transfer Ratio Measurements in the Lumbosacral Enlargement: A Pilot In Vivo Study at 3T.                   PLoS One , 10  (7)    , Article e0134495.  10.1371/journal.pone.0134495 <https://doi.org/10.1371/journal.pone.0134495>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1472451/1/Grey%20and%20White%20Matter%20Magnetisation%20Transfer%20Ratio%20Measurements%20in%20the%20Lumbosacral%20Enlargement%3A%20A%20Pilot%20In%20Vivo%20Study%20at%203T..pdf