eprintid: 1472400
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/01/47/24/00
datestamp: 2015-11-09 14:54:09
lastmod: 2021-09-19 23:41:44
status_changed: 2015-11-09 14:54:09
type: article
metadata_visibility: show
creators_name: Scarpa, E
creators_name: Szabó, A
creators_name: Bibonne, A
creators_name: Theveneau, E
creators_name: Parsons, M
creators_name: Mayor, R
title: Cadherin Switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: F96
note: This is an open access article under the CC BY license (
http://creativecommons.org/licenses/by/4.0/)
abstract: Contact inhibition of locomotion (CIL) is the process through which cells move away from each other after cell-cell contact, and it contributes to malignant invasion and developmental migration. Various cell types exhibit CIL, whereas others remain in contact after collision and may form stable junctions. To investigate what determines this differential behavior, we study neural crest cells, a migratory stem cell population whose invasiveness has been likened to cancer metastasis. By comparing pre-migratory and migratory neural crest cells, we show that the switch from E- to N-cadherin during EMT is essential for acquisition of CIL behavior. Loss of E-cadherin leads to repolarization of protrusions, via p120 and Rac1, resulting in a redistribution of forces from intercellular tension to cell-matrix adhesions, which break down the cadherin junction. These data provide insight into the balance of physical forces that contributes to CIL in cells in vivo.
date: 2015-08-24
date_type: published
official_url: http://dx.doi.org/10.1016/j.devcel.2015.06.012
oa_status: green
full_text_type: pub
pmcid: PMC4552721
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1045384
doi: 10.1016/j.devcel.2015.06.012
pii: S1534-5807(15)00401-3
language_elements: eng
lyricists_name: Mayor, Roberto
lyricists_name: Szabo, Andras
lyricists_id: RMAYO52
lyricists_id: ASZAB39
actors_name: Mayor, Roberto
actors_name: Gibson, Alice
actors_id: RMAYO52
actors_id: AGIBS47
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Developmental Cell
volume: 34
number: 4
pagerange: 421-434
event_location: United States
issn: 1878-1551
citation:        Scarpa, E;    Szabó, A;    Bibonne, A;    Theveneau, E;    Parsons, M;    Mayor, R;      (2015)    Cadherin Switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces.                   Developmental Cell , 34  (4)   pp. 421-434.    10.1016/j.devcel.2015.06.012 <https://doi.org/10.1016/j.devcel.2015.06.012>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1472400/1/1-s2.0-S1534580715004013-main.pdf