eprintid: 1471727 rev_number: 24 eprint_status: archive userid: 608 dir: disk0/01/47/17/27 datestamp: 2015-10-13 14:45:34 lastmod: 2021-09-26 22:24:07 status_changed: 2015-10-13 14:45:34 type: article metadata_visibility: show creators_name: Sadeh, S creators_name: Clopath, C creators_name: Rotter, S title: Processing of Feature Selectivity in Cortical Networks with Specific Connectivity ispublished: pub divisions: UCL divisions: B02 divisions: C08 note: © 2015 Sadeh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited abstract: Although non-specific at the onset of eye opening, networks in rodent visual cortex attain a non-random structure after eye opening, with a specific bias for connections between neurons of similar preferred orientations. As orientation selectivity is already present at eye opening, it remains unclear how this specificity in network wiring contributes to feature selectivity. Using large-scale inhibition-dominated spiking networks as a model, we show that feature-specific connectivity leads to a linear amplification of feedforward tuning, consistent with recent electrophysiological single-neuron recordings in rodent neocortex. Our results show that optimal amplification is achieved at an intermediate regime of specific connectivity. In this configuration a moderate increase of pairwise correlations is observed, consistent with recent experimental findings. Furthermore, we observed that feature-specific connectivity leads to the emergence of orientation-selective reverberating activity, and entails pattern completion in network responses. Our theoretical analysis provides a mechanistic understanding of subnetworks' responses to visual stimuli, and casts light on the regime of operation of sensory cortices in the presence of specific connectivity. date: 2015-06-17 date_type: published official_url: http://dx.doi.org/10.1371/journal.pone.0127547 oa_status: green full_text_type: pub pmcid: PMC4471232 primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1039648 doi: 10.1371/journal.pone.0127547 pii: PONE-D-15-07356 language_elements: eng lyricists_name: Sadeh, Sadra lyricists_id: SSADE65 actors_name: Sadeh, Sadra actors_name: Barczynska, Patrycja actors_id: SSADE65 actors_id: PBARC91 actors_role: owner actors_role: impersonator full_text_status: public publication: PLoS One volume: 10 number: 6 article_number: e0127547 event_location: United States issn: 1932-6203 citation: Sadeh, S; Clopath, C; Rotter, S; (2015) Processing of Feature Selectivity in Cortical Networks with Specific Connectivity. PLoS One , 10 (6) , Article e0127547. 10.1371/journal.pone.0127547 <https://doi.org/10.1371/journal.pone.0127547>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1471727/1/Processing%20of%20Feature%20Selectivity%20in%20Cortical%20Networks%20with%20Specific%20Connectivity..pdf