eprintid: 1471701
rev_number: 27
eprint_status: archive
userid: 608
dir: disk0/01/47/17/01
datestamp: 2015-10-21 10:19:25
lastmod: 2021-10-04 00:52:35
status_changed: 2015-10-21 10:19:25
type: article
metadata_visibility: show
creators_name: Gibson, SM
creators_name: Lanigan, RM
creators_name: Benhamou, L
creators_name: Aliev, AE
creators_name: Sheppard, TD
title: A lactate-derived chiral aldehyde for determining the enantiopurity of enantioenriched primary amines
ispublished: pub
divisions: UCL
divisions: B04
divisions: C06
divisions: F56
note: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: In this paper we describe the use of a chiral aldehyde derived from lactate esters for determining the enantiopurity of primary amines, via the formation of diastereomeric imines. The method was shown to be suitable for reproducibly determining the enantiopurity of a diverse set of chiral amines. Both enantiomers of the aldehyde can be prepared in two steps from commercially available materials.
date: 2015-09-14
date_type: published
official_url: http://dx.doi.org/10.1039/c5ob01398d
oa_status: green
full_text_type: pub
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1045481
doi: 10.1039/c5ob01398d
language_elements: eng
lyricists_name: Aliev, Abil
lyricists_name: Benhamou, Laure
lyricists_name: Sheppard, Thomas
lyricists_id: AEALI75
lyricists_id: LBEHA77
lyricists_id: TSHEP42
actors_name: Sheppard, Thomas
actors_id: TSHEP42
actors_role: owner
full_text_status: public
publication: Organic & Biomolecular Chemistry
volume: 13
number: 34
pagerange: 9050-9054
event_location: England
issn: 1477-0539
citation:        Gibson, SM;    Lanigan, RM;    Benhamou, L;    Aliev, AE;    Sheppard, TD;      (2015)    A lactate-derived chiral aldehyde for determining the enantiopurity of enantioenriched primary amines.                   Organic & Biomolecular Chemistry , 13  (34)   pp. 9050-9054.    10.1039/c5ob01398d <https://doi.org/10.1039/c5ob01398d>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1471701/1/c5ob01398d.pdf