eprintid: 1469147 rev_number: 44 eprint_status: archive userid: 608 dir: disk0/01/46/91/47 datestamp: 2015-08-20 08:53:43 lastmod: 2021-12-13 02:31:14 status_changed: 2015-08-20 08:53:43 type: article metadata_visibility: show item_issues_count: 0 creators_name: Sivaraman, V creators_name: Pickard, JMJ creators_name: Hausenloy, DJ title: Remote ischaemic conditioning: Cardiac protection from afar ispublished: pub divisions: UCL divisions: B02 divisions: D14 divisions: GA2 note: Copyright © 2015 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists of Great Britain and Ireland. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: For patients with ischaemic heart disease, remote ischaemic conditioning may offer an innovative, non-invasive and virtually cost-free therapy for protecting the myocardium against the detrimental effects of acute ischaemia-reperfusion injury, preserving cardiac function and improving clinical outcomes. The intriguing phenomenon of remote ischaemic conditioning was first discovered over 20 years ago, when it was shown that the heart could be rendered resistant to acute ischaemia-reperfusion injury by applying one or more cycles of brief ischaemia and reperfusion to an organ or tissue away from the heart - initially termed 'cardioprotection at a distance'. Subsequent pre-clinical and then clinical studies made the important discovery that remote ischaemic conditioning could be elicited non-invasively, by inducing brief ischaemia and reperfusion to the upper or lower limb using a cuff. The actual mechanism underlying remote ischaemic conditioning cardioprotection remains unclear, although a neuro-hormonal pathway has been implicated. Since its initial discovery in 1993, the first proof-of-concept clinical studies of remote ischaemic conditioning followed in 2006, and now multicentre clinical outcome studies are underway. In this review article, we explore the potential mechanisms underlying this academic curiosity, and assess the success of its application in the clinical setting. date: 2015-06-01 official_url: http://dx.doi.org/ 10.1111/anae.12973 vfaculties: VFPHS oa_status: green full_text_type: pub primo: open primo_central: open_green verified: verified_manual elements_source: Scopus elements_id: 1034677 doi: 10.1111/anae.12973 publication_declined: 2015-08-30T11:33:40BST publication_deleted: 2015-08-30T11:33:40BST lyricists_name: Hausenloy, Derek lyricists_id: DHAUS05 full_text_status: public publication: Anaesthesia volume: 70 number: 6 pagerange: 732 - 748 issn: 0003-2409 citation: Sivaraman, V; Pickard, JMJ; Hausenloy, DJ; (2015) Remote ischaemic conditioning: Cardiac protection from afar. Anaesthesia , 70 (6) 732 - 748. 10.1111/anae.12973 <https://doi.org/10.1111/anae.12973>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1469147/6/Hausenloy_Anesthesia_1469147.pdf