eprintid: 1469147
rev_number: 44
eprint_status: archive
userid: 608
dir: disk0/01/46/91/47
datestamp: 2015-08-20 08:53:43
lastmod: 2021-12-13 02:31:14
status_changed: 2015-08-20 08:53:43
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Sivaraman, V
creators_name: Pickard, JMJ
creators_name: Hausenloy, DJ
title: Remote ischaemic conditioning: Cardiac protection from afar
ispublished: pub
divisions: UCL
divisions: B02
divisions: D14
divisions: GA2
note: Copyright © 2015 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists of Great Britain and Ireland. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
abstract: For patients with ischaemic heart disease, remote ischaemic conditioning may offer an innovative, non-invasive and virtually cost-free therapy for protecting the myocardium against the detrimental effects of acute ischaemia-reperfusion injury, preserving cardiac function and improving clinical outcomes. The intriguing phenomenon of remote ischaemic conditioning was first discovered over 20 years ago, when it was shown that the heart could be rendered resistant to acute ischaemia-reperfusion injury by applying one or more cycles of brief ischaemia and reperfusion to an organ or tissue away from the heart - initially termed 'cardioprotection at a distance'. Subsequent pre-clinical and then clinical studies made the important discovery that remote ischaemic conditioning could be elicited non-invasively, by inducing brief ischaemia and reperfusion to the upper or lower limb using a cuff. The actual mechanism underlying remote ischaemic conditioning cardioprotection remains unclear, although a neuro-hormonal pathway has been implicated. Since its initial discovery in 1993, the first proof-of-concept clinical studies of remote ischaemic conditioning followed in 2006, and now multicentre clinical outcome studies are underway. In this review article, we explore the potential mechanisms underlying this academic curiosity, and assess the success of its application in the clinical setting.
date: 2015-06-01
official_url: http://dx.doi.org/ 10.1111/anae.12973
vfaculties: VFPHS
oa_status: green
full_text_type: pub
primo: open
primo_central: open_green
verified: verified_manual
elements_source: Scopus
elements_id: 1034677
doi: 10.1111/anae.12973
publication_declined: 2015-08-30T11:33:40BST
publication_deleted: 2015-08-30T11:33:40BST
lyricists_name: Hausenloy, Derek
lyricists_id: DHAUS05
full_text_status: public
publication: Anaesthesia
volume: 70
number: 6
pagerange: 732 - 748
issn: 0003-2409
citation:        Sivaraman, V;    Pickard, JMJ;    Hausenloy, DJ;      (2015)    Remote ischaemic conditioning: Cardiac protection from afar.                   Anaesthesia , 70  (6)   732 - 748.    10.1111/anae.12973 <https://doi.org/10.1111/anae.12973>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1469147/6/Hausenloy_Anesthesia_1469147.pdf