<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1468840> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/title> "Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/abstract> "Background:\r\nAlzheimer’s disease (AD) is a highly heritable disease, but until recently few replicated genetic markers have\r\nbeen identified. Markers identified so far are likely to account for only a tiny fraction of the heritability of AD and many more\r\ngenetic risk alleles are thought to be undiscovered.\r\nObjective:\r\nIdentifying genetic markers for AD using combined analysis of genetics and brain imaging data.\r\nMethods:\r\nImaging quantitative trait loci (iQTLs) has recently emerged as an interesting research area for linking genetics of\r\nbrain changes to AD. We consider a genome-wide association scan of 109 brain-wide regional imaging phenotypes to identify\r\ngenetic susceptibility loci for AD from a combined set of 1,045 subjects from the Alzheimer’s Disease Neuroimaging Initiative\r\n(ADNI) and the AddNeuroMed studies. We use one-SNP-at-a-time as well as multi-SNP Hyperlasso based iQTL methods for\r\nthe analysis. Results:\r\nWe identified several novel markers associated with AD, namely HOMER2 (rs1256429; intronic,\r\np\r\n= 8.7\r\n×\r\n10\r\n–\r\n10\r\n),\r\nEOMES (rs2724509; flanking), JAM2 (rs2829841; intronic), and WEE1 (rs10770042; coding). The SNP rs1256429 (HOMER2)\r\nwas one of the top hits in Hyperlasso as well as in the single-SNP analysis showing an association with the volume of the right\r\nthalamus and AD, a brain region reported to be linked with AD in several studies.\r\nConclusion:\r\nWe believe that the markers identified in this study are novel additions to the existing list of genetic variants\r\nassociated with AD which can be validated in future replicated studies"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/date> "2015" .
<https://discovery.ucl.ac.uk/id/document/139848> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/volume> "45" .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/issue> "3" .
<https://discovery.ucl.ac.uk/id/publication/ext-13872877> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-13872877> <http://xmlns.com/foaf/0.1/name> "Journal of Alzheimer's Disease"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-13872877> .
<https://discovery.ucl.ac.uk/id/publication/ext-13872877> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:13872877> .
<https://discovery.ucl.ac.uk/id/publication/ext-13872877> <http://purl.org/ontology/bibo/issn> "13872877" .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-df1b1780aeb2c0b75d508a60c2d126ef> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1468840#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1468840#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-df1b1780aeb2c0b75d508a60c2d126ef> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-232173ff940d610b517073b8e436adb8> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1468840#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1468840#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-232173ff940d610b517073b8e436adb8> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-efc166cf1efa3d21fba4ae563af398d9> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1468840#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1468840#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-efc166cf1efa3d21fba4ae563af398d9> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d1660abcbc6a698f1acf93b7eb28e1aa> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1468840#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1468840#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-d1660abcbc6a698f1acf93b7eb28e1aa> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7be4c2e95a474ebbc10da53af7ef66a6> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1468840#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1468840#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-7be4c2e95a474ebbc10da53af7ef66a6> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-231447d9a8b26ce8f4e850d26e06068b> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1468840#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1468840#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-231447d9a8b26ce8f4e850d26e06068b> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c9aff679ebe33c3a89675c8f2a3765a2> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1468840#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1468840#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-c9aff679ebe33c3a89675c8f2a3765a2> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9dd488057e98247a821f96e7db6f1bd5> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1468840#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1468840#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-9dd488057e98247a821f96e7db6f1bd5> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ba66d2d27521f0e08f85cd7f48736d1d> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1468840#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1468840#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-ba66d2d27521f0e08f85cd7f48736d1d> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-78345695d960da830a4093a4455088cc> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1468840#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1468840#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-78345695d960da830a4093a4455088cc> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7e8ef9adb4ee4a5c24fecd74be3228ce> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1468840#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1468840#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-7e8ef9adb4ee4a5c24fecd74be3228ce> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-182c39d58472ede09d17fa44f1d563dd> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1468840#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1468840#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-182c39d58472ede09d17fa44f1d563dd> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e30db6e1859aeeb589c55bc6156525f6> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1468840#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1468840#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-e30db6e1859aeeb589c55bc6156525f6> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-325dd26263d9499a76dd185ee1f6b073> .
<https://discovery.ucl.ac.uk/id/eprint/1468840> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1468840#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1468840#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-325dd26263d9499a76dd185ee1f6b073> .
<https://discovery.ucl.ac.uk/id/person/ext-d1660abcbc6a698f1acf93b7eb28e1aa> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d1660abcbc6a698f1acf93b7eb28e1aa> <http://xmlns.com/foaf/0.1/givenName> "JS"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d1660abcbc6a698f1acf93b7eb28e1aa> <http://xmlns.com/foaf/0.1/familyName> "Muehlboeck"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d1660abcbc6a698f1acf93b7eb28e1aa> <http://xmlns.com/foaf/0.1/name> "JS Muehlboeck"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9dd488057e98247a821f96e7db6f1bd5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9dd488057e98247a821f96e7db6f1bd5> <http://xmlns.com/foaf/0.1/givenName> "I"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9dd488057e98247a821f96e7db6f1bd5> <http://xmlns.com/foaf/0.1/familyName> "KÅ‚oszewska"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9dd488057e98247a821f96e7db6f1bd5> <http://xmlns.com/foaf/0.1/name> "I KÅ‚oszewska"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-232173ff940d610b517073b8e436adb8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-232173ff940d610b517073b8e436adb8> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-232173ff940d610b517073b8e436adb8> <http://xmlns.com/foaf/0.1/familyName> "Newhouse"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-232173ff940d610b517073b8e436adb8> <http://xmlns.com/foaf/0.1/name> "S Newhouse"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-df1b1780aeb2c0b75d508a60c2d126ef> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-df1b1780aeb2c0b75d508a60c2d126ef> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-df1b1780aeb2c0b75d508a60c2d126ef> <http://xmlns.com/foaf/0.1/familyName> "Khondoker"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-df1b1780aeb2c0b75d508a60c2d126ef> <http://xmlns.com/foaf/0.1/name> "M Khondoker"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-78345695d960da830a4093a4455088cc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-78345695d960da830a4093a4455088cc> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-78345695d960da830a4093a4455088cc> <http://xmlns.com/foaf/0.1/familyName> "Lovestone"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-78345695d960da830a4093a4455088cc> <http://xmlns.com/foaf/0.1/name> "S Lovestone"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ba66d2d27521f0e08f85cd7f48736d1d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ba66d2d27521f0e08f85cd7f48736d1d> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ba66d2d27521f0e08f85cd7f48736d1d> <http://xmlns.com/foaf/0.1/familyName> "Soininen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ba66d2d27521f0e08f85cd7f48736d1d> <http://xmlns.com/foaf/0.1/name> "H Soininen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-231447d9a8b26ce8f4e850d26e06068b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-231447d9a8b26ce8f4e850d26e06068b> <http://xmlns.com/foaf/0.1/givenName> "B"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-231447d9a8b26ce8f4e850d26e06068b> <http://xmlns.com/foaf/0.1/familyName> "Vellas"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-231447d9a8b26ce8f4e850d26e06068b> <http://xmlns.com/foaf/0.1/name> "B Vellas"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7be4c2e95a474ebbc10da53af7ef66a6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7be4c2e95a474ebbc10da53af7ef66a6> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7be4c2e95a474ebbc10da53af7ef66a6> <http://xmlns.com/foaf/0.1/familyName> "Mecocci"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7be4c2e95a474ebbc10da53af7ef66a6> <http://xmlns.com/foaf/0.1/name> "P Mecocci"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7e8ef9adb4ee4a5c24fecd74be3228ce> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7e8ef9adb4ee4a5c24fecd74be3228ce> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7e8ef9adb4ee4a5c24fecd74be3228ce> <http://xmlns.com/foaf/0.1/familyName> "Dobson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7e8ef9adb4ee4a5c24fecd74be3228ce> <http://xmlns.com/foaf/0.1/name> "R Dobson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c9aff679ebe33c3a89675c8f2a3765a2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c9aff679ebe33c3a89675c8f2a3765a2> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c9aff679ebe33c3a89675c8f2a3765a2> <http://xmlns.com/foaf/0.1/familyName> "Tsolaki"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c9aff679ebe33c3a89675c8f2a3765a2> <http://xmlns.com/foaf/0.1/name> "M Tsolaki"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-efc166cf1efa3d21fba4ae563af398d9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-efc166cf1efa3d21fba4ae563af398d9> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-efc166cf1efa3d21fba4ae563af398d9> <http://xmlns.com/foaf/0.1/familyName> "Westman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-efc166cf1efa3d21fba4ae563af398d9> <http://xmlns.com/foaf/0.1/name> "E Westman"^^<http://www.w3.org/2001/XMLSchema#string> .
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