eprintid: 1467384
rev_number: 25
eprint_status: archive
userid: 608
dir: disk0/01/46/73/84
datestamp: 2015-04-29 05:52:15
lastmod: 2021-11-01 01:58:42
status_changed: 2015-04-29 05:52:15
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Rossi, D
creators_name: Gavriilidis, A
creators_name: Candel, MA
creators_name: Jones, AG
creators_name: Mazzei, L
creators_name: Kuhn, S
creators_name: Price, C
title: Adipic acid primary nucleation kinetics from probability distributions in droplet-based systems under stagnant and flow conditions
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F43
note: © 2015 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
abstract: In this work, we present a microfluidic approach that allows performing nucleation studies under different fluid dynamic conditions. We determine primary nucleation rates and nucleation kinetic parameters for adipic acid solutions by using liquid/liquid segmented flow in capillary tubes in which the crystallizing medium is partitioned into small droplets. We do so by measuring the probability of crystal presence within individual droplets under stagnant (motionless droplets) and flow (moving droplets) conditions as a function of time, droplet volume, and supersaturation. Comparing the results of the experiments with the predictions of the classical nucleation theory model and of the mononuclear nucleation mechanism model, we conclude that adipic acid nucleates mainly via a heterogeneous mechanism under both fluid dynamic conditions. Furthermore, we show that the flow conditions enhance the primary nucleation rate by increasing the kinetic parameters of the process without affecting the thermodynamic parameters. In this regard, a possible mechanism is discussed on the basis of the enhancement of the attachment frequency of nucleation caused by the internal recirculation that occurs within moving droplets.
date: 2015-04-01
official_url: http://dx.doi.org/10.1021/cg501836e
vfaculties: VENG
oa_status: green
full_text_type: pub
primo: open
primo_central: open_green
verified: verified_manual
elements_source: Scopus
elements_id: 1027496
doi: 10.1021/cg501836e
lyricists_name: Gavriilidis, Asterios
lyricists_name: Mazzei, Luca
lyricists_id: AGAVR68
lyricists_id: LMAZZ90
full_text_status: public
publication: Crystal Growth and Design
volume: 15
number: 4
pagerange: 1784 - 1791
issn: 1528-7483
citation:        Rossi, D;    Gavriilidis, A;    Candel, MA;    Jones, AG;    Mazzei, L;    Kuhn, S;    Price, C;      (2015)    Adipic acid primary nucleation kinetics from probability distributions in droplet-based systems under stagnant and flow conditions.                   Crystal Growth and Design , 15  (4)   1784 - 1791.    10.1021/cg501836e <https://doi.org/10.1021/cg501836e>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1467384/1/cg501836e.pdf