eprintid: 1467365
rev_number: 33
eprint_status: archive
userid: 608
dir: disk0/01/46/73/65
datestamp: 2015-04-29 05:29:05
lastmod: 2023-02-06 11:49:40
status_changed: 2015-04-29 05:29:05
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Martinez-Barbera, JP
title: Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma
ispublished: pub
divisions: UCL
divisions: B02
divisions: D13
divisions: G22
keywords: Sox2, WNT pathway, adamantinomatous craniopharyngioma, pituitary, stem cells, β-catenin
note: © 2015 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
abstract: Adamantinomatous craniopharyngiomas (ACPs) are the most common pituitary tumours in children. Although histologically benign, these are clinically aggressive tumours, difficult to manage and associated with poor quality of life for the patients. Several human and mouse studies have provided unequivocal evidence that the over-activation of the WNT/β-catenin signalling pathway underlies the molecular aetiology of these tumours. Recently, research using genetically modified mouse models of human ACP have revealed a critical and unexpected non-cell autonomous role for pituitary stem cells in ACP tumourigenesis, which has expanded the cancer stem cell paradigm. As the result of this basic research, the pathogenesis of ACP is being unveiled, with promising implications for the development of novel treatments against these childhood neoplasms. These benign tumours may additionally represent a unique model to provide insights into the initial steps of oncogenesis.
date: 2015-01-22
official_url: http://dx.doi.org/10.1111/nan.12226
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_source: PubMed
elements_id: 1011014
doi: 10.1111/nan.12226
lyricists_name: Martinez-Barbera, Juan
lyricists_id: JPMAR49
full_text_status: public
publication: Neuropathology and Applied Neurobiology
volume: 41
number: 6
pagerange: 721-732
citation:        Martinez-Barbera, JP;      (2015)    Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma.                   Neuropathology and Applied Neurobiology , 41  (6)   pp. 721-732.    10.1111/nan.12226 <https://doi.org/10.1111/nan.12226>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1467365/3/Martinez-Barbera_Neuropathology%20Appl%20Neurobio%20-%202015%20-%20Martinez%E2%80%90Barbera%20-%20Molecular%20and%20cellular%20pathogenesis%20of%20adamantinomatous.pdf