eprintid: 1467106 rev_number: 30 eprint_status: archive userid: 608 dir: disk0/01/46/71/06 datestamp: 2015-04-22 21:25:03 lastmod: 2021-09-26 22:44:47 status_changed: 2015-04-22 21:25:03 type: article metadata_visibility: show item_issues_count: 0 creators_name: Halpern, AR creators_name: Golden, HL creators_name: Magdalinou, N creators_name: Witoonpanich, P creators_name: Warren, JD title: Musical tasks targeting preserved and impaired functions in two dementias. ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F86 keywords: Alzheimer's disease, Parkinson's disease, auditory imagery, executive function, Aged, Alzheimer Disease, Auditory Perception, Behavior, Cognition, Dementia, Executive Function, Female, Humans, Learning, Male, Middle Aged, Music, Neuropsychological Tests, Parkinson Disease, Perception note: © 2014 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals Inc. on behalf of The New York Academy of Sciences. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: Studies of musical abilities in dementia have for the most part been rather general assessments of abilities, for instance, assessing retention of music learned premorbidly. Here, we studied patients with dementias with contrasting cognitive profiles to explore specific aspects of music cognition under challenge. Patients suffered from Alzheimer's disease (AD), in which a primary impairment is in forming new declarative memories, or Lewy body disease (PD/LBD), a type of parkinsonism in which executive impairments are prominent. In the AD patients, we examined musical imagery. Behavioral and neural evidence confirms involvement of perceptual networks in imagery, and these are relatively spared in early stages of the illness. Thus, we expected patients to have relatively intact imagery in a mental pitch comparison task. For the LBD patients, we tested whether executive dysfunction would extend to music. We probed inhibitory skills by asking for a speeded pitch or timbre judgment when the irrelevant dimension was held constant or also changed. Preliminary results show that AD patients score similarly to controls in the imagery tasks, but PD/LBD patients are impaired relative to controls in suppressing some irrelevant musical dimensions, particularly when the required judgment varies from trial to trial. date: 2015-03 official_url: http://dx.doi.org/10.1111/nyas.12616 vfaculties: VFBRS oa_status: green full_text_type: pub primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_source: PubMed elements_id: 1021239 doi: 10.1111/nyas.12616 lyricists_name: Golden, Hannah lyricists_name: Warren, Jason lyricists_id: HLGOL19 lyricists_id: JDWAR75 full_text_status: public publication: Ann N Y Acad Sci volume: 1337 pagerange: 241-248 event_location: United States issn: 1749-6632 citation: Halpern, AR; Golden, HL; Magdalinou, N; Witoonpanich, P; Warren, JD; (2015) Musical tasks targeting preserved and impaired functions in two dementias. Ann N Y Acad Sci , 1337 pp. 241-248. 10.1111/nyas.12616 <https://doi.org/10.1111/nyas.12616>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1467106/1/nyas12616.pdf