eprintid: 1466816 rev_number: 33 eprint_status: archive userid: 608 dir: disk0/01/46/68/16 datestamp: 2015-04-21 19:27:32 lastmod: 2022-01-16 00:58:08 status_changed: 2015-04-21 19:27:32 type: article metadata_visibility: show item_issues_count: 0 creators_name: Scharnowski, F creators_name: Veit, R creators_name: Zopf, R creators_name: Studer, P creators_name: Bock, S creators_name: Diedrichsen, J creators_name: Goebel, R creators_name: Mathiak, K creators_name: Birbaumer, N creators_name: Weiskopf, N title: Manipulating motor performance and memory through real-time fMRI neurofeedback ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F83 keywords: Brain imaging, Brain training, Functional magnetic resonance imaging (fMRI), Memory, Motor performance, Neurofeedback, Real-time fMRI, Self-regulation note: © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license(http://creativecommons.org/licenses/by/4.0/). abstract: Task performance depends on ongoing brain activity which can be influenced by attention, arousal, or motivation. However, such modulating factors of cognitive efficiency are unspecific, can be difficult to control, and are not suitable to facilitate neural processing in a regionally specific manner. Here, we non-pharmacologically manipulated regionally specific brain activity using technically sophisticated real-time fMRI neurofeedback. This was accomplished by training participants to simultaneously control ongoing brain activity in circumscribed motor and memory-related brain areas, namely the supplementary motor area and the parahippocampal cortex. We found that learned voluntary control over these functionally distinct brain areas caused functionally specific behavioral effects, i.e. shortening of motor reaction times and specific interference with memory encoding. The neurofeedback approach goes beyond improving cognitive efficiency by unspecific psychological factors such as attention, arousal, or motivation. It allows for directly manipulating sustained activity of task-relevant brain regions in order to yield specific behavioral or cognitive effects. date: 2015-05 official_url: http://dx.doi.org/10.1016/j.biopsycho.2015.03.009 vfaculties: VFBRS oa_status: green full_text_type: pub primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_source: PubMed elements_id: 1021110 doi: 10.1016/j.biopsycho.2015.03.009 pii: S0301-0511(15)00067-8 language_elements: ENG lyricists_name: Diedrichsen, Joern lyricists_name: Weiskopf, Nikolaus lyricists_id: JDIED89 lyricists_id: NWEIS04 full_text_status: public publication: Biological Psychology volume: 108 pagerange: 85-97 event_location: Netherlands issn: 1873-6246 citation: Scharnowski, F; Veit, R; Zopf, R; Studer, P; Bock, S; Diedrichsen, J; Goebel, R; ... Weiskopf, N; + view all <#> Scharnowski, F; Veit, R; Zopf, R; Studer, P; Bock, S; Diedrichsen, J; Goebel, R; Mathiak, K; Birbaumer, N; Weiskopf, N; - view fewer <#> (2015) Manipulating motor performance and memory through real-time fMRI neurofeedback. Biological Psychology , 108 pp. 85-97. 10.1016/j.biopsycho.2015.03.009 <https://doi.org/10.1016/j.biopsycho.2015.03.009>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1466816/1/Manipulating%20motor%20performance%20and%20memory%20through%20real-time%20fMRI%20neurofeedback.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/1466816/2/Supplementary%20data.doc