eprintid: 1466481
rev_number: 31
eprint_status: archive
userid: 608
dir: disk0/01/46/64/81
datestamp: 2015-04-17 14:59:13
lastmod: 2021-10-04 02:02:02
status_changed: 2015-04-17 14:59:13
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Tullet, JMA
title: DAF-16 target identification in C. elegans: past, present and future
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
keywords: Ageing, C. elegans, DAF-16, Insulin/IGF-1 like signalling, mRNA profiling, Proteomics
note: Copyright © The Author(s) 2014. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution License which permits any use,distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
abstract: In C. elegans , mutations in the conserved insulin/IGF-1 signaling (IIS) pathway lead to a robust extension in lifespan, improved late life health, and protection from age-related disease. These effects are mediated by the FoxO transcription factor DAF-16 which lies downstream of the IIS kinase cascade. Identifying and functionally testing DAF-16 target genes has been a focal point of ageing research for the last 10 years. Here, I review the recent advances in identifying and understanding IIS/DAF-16 targets. These studies continue to reveal the intricate nature of the IIS/DAF-16 gene regulation network and are helping us to understand the mechanisms that control lifespan. Ageing and age related disease is an area of intense public interest, and the biochemical charac- terization of the genes involved will be critical for identifying drugs to improve the health of our ageing population.
date: 2015-04
official_url: http://dx.doi.org/10.1007/s10522-014-9527-y
vfaculties: VFLS
oa_status: green
full_text_type: pub
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_source: Manually entered
elements_id: 1026546
doi: 10.1007/s10522-014-9527-y
lyricists_name: Tullet, Jennifer
lyricists_id: JTULL54
full_text_status: public
publication: Biogerontology
volume: 16
number: 2
pagerange: 221 - 234
issn: 1389-5729
citation:        Tullet, JMA;      (2015)    DAF-16 target identification in C. elegans: past, present and future.                   Biogerontology , 16  (2)   221 - 234.    10.1007/s10522-014-9527-y <https://doi.org/10.1007/s10522-014-9527-y>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1466481/1/Tullet.art%253A10.1007%252Fs10522-014-9527-y.pdf