eprintid: 1466311
rev_number: 43
eprint_status: archive
userid: 608
dir: disk0/01/46/63/11
datestamp: 2015-04-16 19:39:56
lastmod: 2021-12-13 02:43:26
status_changed: 2017-04-11 09:53:16
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Child, N
creators_name: Bishop, MJ
creators_name: Hanson, B
creators_name: Coronel, R
creators_name: Opthof, T
creators_name: Boukens, BJ
creators_name: Walton, RD
creators_name: Efimov, IR
creators_name: Bostock, J
creators_name: Hill, Y
creators_name: Rinaldi, CA
creators_name: Razavi, R
creators_name: Gill, J
creators_name: Taggart, P
title: An activation-repolarization time metric to predict localized regions of high susceptibility to reentry
ispublished: pub
divisions: UCL
divisions: B02
divisions: D14
divisions: B04
divisions: C05
divisions: F45
keywords: Arrhythmia; ventricular tachycardia; ablation
note: Copyright © 2015. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. Access may be initially restricted by the publisher.
abstract: BACKGROUND Initiation of reentrant ventricular tachycardia (VT)involves complex interactions between front and tail of the activation wave. Recent experimental work has identified the time interval between S2 repolarization proximal to a line of functional block and S2 activation at the adjacent distal side as a critical determinant of reentry.
OBJECTIVES We hypothesized that (1) an algorithm could be
developed to generate a spatial map of this interval (“reentry vulnerability index” [RVI]), (2) this would accurately identify a site of reentry without the need to actually induce the arrhythmia, and (3) it would be possible to generate an RVI map in patients during
routine clinical procedures.
METHODS An algorithm was developed that calculated RVI
between all pairs of electrodes within a given radius.
RESULTS The algorithm successfully identified the region with increased susceptibility to reentry in an established Langendorff pig heart model and the site of reentry and rotor formation in an optically mapped sheep ventricular preparation and computational simulations. The feasibility of RVI mapping was evaluated during a
clinical procedure by coregistering with cardiac anatomy and physiology of a patient undergoing VT ablation.
CONCLUSION We developed an algorithm to calculate a reentry vulnerability index from intervals between local repolarization and activation. The algorithm accurately identified the region of reentry in 2 animal models of functional reentry. The clinical application was demonstrated in a patient with VT and identified the area of reentry without the need of inducing the arrhythmia.
date: 2015-07
publisher: ELSEVIER SCIENCE INC
official_url: http://dx.doi.org/10.1016/j.hrthm.2015.04.013
vfaculties: VENG
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_source: PubMed
elements_id: 1025942
doi: 10.1016/j.hrthm.2015.04.013
lyricists_name: Hanson, Benjamin
lyricists_name: Taggart, Peter
lyricists_id: BMHAN48
lyricists_id: PITAG68
full_text_status: public
publication: Heart Rhythm
volume: 12
number: 7
pagerange: 1644-1653
pages: 10
issn: 1547-5271
citation:        Child, N;    Bishop, MJ;    Hanson, B;    Coronel, R;    Opthof, T;    Boukens, BJ;    Walton, RD;                             ... Taggart, P; + view all <#>        Child, N;  Bishop, MJ;  Hanson, B;  Coronel, R;  Opthof, T;  Boukens, BJ;  Walton, RD;  Efimov, IR;  Bostock, J;  Hill, Y;  Rinaldi, CA;  Razavi, R;  Gill, J;  Taggart, P;   - view fewer <#>    (2015)    An activation-repolarization time metric to predict localized regions of high susceptibility to reentry.                   Heart Rhythm , 12  (7)   pp. 1644-1653.    10.1016/j.hrthm.2015.04.013 <https://doi.org/10.1016/j.hrthm.2015.04.013>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1466311/1/Hanson_emss-66261.pdf