eprintid: 1465969
rev_number: 33
eprint_status: archive
userid: 608
dir: disk0/01/46/59/69
datestamp: 2015-04-14 12:21:06
lastmod: 2021-09-20 00:31:08
status_changed: 2015-04-14 12:21:06
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Bader, A
creators_name: Martini, F
creators_name: Schinella, GR
creators_name: Rios, JL
creators_name: Prieto, JM
title: Modulation of Cox-1, 5-, 12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G09
keywords: Acanthaceae, Asteraceae, herbal medicine, leukotrienes, prostaglandins, psoriasis, Acanthaceae, Achillea, Animals, Anti-Inflammatory Agents, Arachidonate Lipoxygenases, Artemisia, Blood Platelets, Cyclooxygenase 1, Dermatologic Agents, HeLa Cells, Humans, Inula, Italy, Leukocytes, NF-kappa B, Phytotherapy, Plant Extracts, Plants, Medicinal, Psoriasis, Rats, Skin Diseases
note: Copyright © 2014 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
abstract: Acanthus mollis (Acanthaceae), Achillea ligustica, Artemisia arborescens and Inula viscosa (Asteraceae) are used in Southern Italy against psoriasis and other skin diseases that occur with an imbalanced production of eicosanoids. We here assessed their in vitro effects upon 5-, 12-, 15-LOX and COX-1 enzymes as well as NFκB activation in intact cells as their possible therapeutic targets. All methanol crude extracts inhibited both 5-LOX and COX-1 activities under 200 µg/mL, without significant effects on the 12-LOX pathway or any relevant in vitro free radical scavenging activity. NFκB activation was prevented by all extracts but A. mollis. Interestingly, A. ligustica, A. arborescens and A. mollis increased the biosynthesis of 15(S)-HETE, an anti-inflammatory eicosanoid. A. ligustica (IC50 =49.5 µg/mL) was superior to Silybum marianum (IC50 =147.8 µg/mL), which we used as antipsoriatic herbal medicine of reference. Its n-hexane, dichloromethane and ethyl acetate fractions had also inhibitory effects on the LTB4 biosynthesis (IC50 s=9.6, 20.3 and 68 µg/mL, respectively) evidencing that the apolar extracts of A. ligustica are promising active herbal ingredients for future phytotherapeutical products targeting psoriasis.
date: 2015-01
official_url: http://dx.doi.org/10.1002/ptr.5234
vfaculties: VFLS
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article, Research Support, Non-U.S. Gov't
verified: verified_manual
elements_source: PubMed
elements_id: 1010622
doi: 10.1002/ptr.5234
lyricists_name: Prieto Garcia, Jose
lyricists_id: JPRIE37
full_text_status: public
publication: Phytother Res
volume: 29
number: 1
pagerange: 108 - 113
event_location: England
citation:        Bader, A;    Martini, F;    Schinella, GR;    Rios, JL;    Prieto, JM;      (2015)    Modulation of Cox-1, 5-, 12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases.                   Phytother Res , 29  (1)   108 - 113.    10.1002/ptr.5234 <https://doi.org/10.1002/ptr.5234>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1465969/1/Modulation%20of%20Cox-1%2C%205-%2C%2012-%20and%2015-Lox%20by%20popular%20herbal%20remedies%20used%20in%20southern%20Italy%20against%20psoriasis%20and%20other%20skin%20diseases..pdf