@article{discovery1465969,
            note = {Copyright {\copyright} 2014 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.},
           title = {Modulation of Cox-1, 5-, 12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases.},
           pages = {108 -- 113},
          volume = {29},
         journal = {Phytother Res},
           month = {January},
          number = {1},
            year = {2015},
          author = {Bader, A and Martini, F and Schinella, GR and Rios, JL and Prieto, JM},
             url = {http://dx.doi.org/10.1002/ptr.5234},
        keywords = {Acanthaceae, Asteraceae, herbal medicine, leukotrienes, prostaglandins, psoriasis, Acanthaceae, Achillea, Animals, Anti-Inflammatory Agents, Arachidonate Lipoxygenases, Artemisia, Blood Platelets, Cyclooxygenase 1, Dermatologic Agents, HeLa Cells, Humans, Inula, Italy, Leukocytes, NF-kappa B, Phytotherapy, Plant Extracts, Plants, Medicinal, Psoriasis, Rats, Skin Diseases},
        abstract = {Acanthus mollis (Acanthaceae), Achillea ligustica, Artemisia arborescens and Inula viscosa (Asteraceae) are used in Southern Italy against psoriasis and other skin diseases that occur with an imbalanced production of eicosanoids. We here assessed their in vitro effects upon 5-, 12-, 15-LOX and COX-1 enzymes as well as NF{\ensuremath{\kappa}}B activation in intact cells as their possible therapeutic targets. All methanol crude extracts inhibited both 5-LOX and COX-1 activities under 200 ug/mL, without significant effects on the 12-LOX pathway or any relevant in vitro free radical scavenging activity. NF{\ensuremath{\kappa}}B activation was prevented by all extracts but A. mollis. Interestingly, A. ligustica, A. arborescens and A. mollis increased the biosynthesis of 15(S)-HETE, an anti-inflammatory eicosanoid. A. ligustica (IC50 =49.5 ug/mL) was superior to Silybum marianum (IC50 =147.8 ug/mL), which we used as antipsoriatic herbal medicine of reference. Its n-hexane, dichloromethane and ethyl acetate fractions had also inhibitory effects on the LTB4 biosynthesis (IC50 s=9.6, 20.3 and 68 ug/mL, respectively) evidencing that the apolar extracts of A. ligustica are promising active herbal ingredients for future phytotherapeutical products targeting psoriasis.}
}