eprintid: 1465428
rev_number: 44
eprint_status: archive
userid: 608
dir: disk0/01/46/54/28
datestamp: 2015-04-10 18:38:13
lastmod: 2021-11-30 00:26:21
status_changed: 2015-04-16 12:47:10
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Peach, T
creators_name: Cornhill, JF
creators_name: Nguyen, A
creators_name: Riina, H
creators_name: Ventikos, Y
title: The 'Sphere': A Dedicated Bifurcation Aneurysm Flow-Diverter Device.
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F45
keywords: CFD, Medical devices, Minimally invasive, Neurovascular, PED, SILK, Shear stress, Stent, Thrombosis, WEB, WSS
note: Copyright © 2014 The Author(s). This article is published with open access at Springerlink.com
abstract: We present flow-based results from the early stage design cycle, based on computational modeling, of a prototype flow-diverter device, known as the 'Sphere', intended to treat bifurcation aneurysms of the cerebral vasculature. The device is available in a range of diameters and geometries and is constructed from a single loop of NITINOL(®) wire. The 'Sphere' reduces aneurysm inflow by means of a high-density, patterned, elliptical surface that partially occludes the aneurysm neck. The device is secured in the healthy parent vessel by two armatures in the shape of open loops, resulting in negligible disruption of parent or daughter vessel flow. The device is virtually deployed in six anatomically accurate bifurcation aneurysms: three located at the Basilar tip and three located at the terminus bifurcation of the Internal Carotid artery (at the meeting of the middle cerebral and anterior cerebral arteries). Both steady state and transient flow simulations reveal that the device presents with a range of aneurysm inflow reductions, with mean flow reductions falling in the range of 30.6-71.8% across the different geometries. A significant difference is noted between steady state and transient simulations in one geometry, where a zone of flow recirculation is not captured in the steady state simulation. Across all six aneurysms, the device reduces the WSS magnitude within the aneurysm sac, resulting in a hemodynamic environment closer to that of a healthy vessel. We conclude from extensive CFD analysis that the 'Sphere' device offers very significant levels of flow reduction in a number of anatomically accurate aneurysm sizes and locations, with many advantages compared to current clinical cylindrical flow-diverter designs. Analysis of the device's mechanical properties and deployability will follow in future publications.
date: 2014-12-01
official_url: http://dx.doi.org/10.1007/s13239-014-0188-4
vfaculties: VENG
oa_status: green
full_text_type: pub
primo: open
primo_central: open_green
article_type_text: JOURNAL ARTICLE
verified: verified_manual
elements_source: PubMed
elements_id: 1003511
doi: 10.1007/s13239-014-0188-4
pii: 188
language_elements: ENG
lyricists_name: Peach, Thomas
lyricists_name: Ventikos, Yiannis
lyricists_id: TPEAC13
lyricists_id: YVENT41
full_text_status: public
publication: Cardiovasc Eng Technol
volume: 5
number: 4
pagerange: 334 - 347
issn: 1869-408X
citation:        Peach, T;    Cornhill, JF;    Nguyen, A;    Riina, H;    Ventikos, Y;      (2014)    The 'Sphere': A Dedicated Bifurcation Aneurysm Flow-Diverter Device.                   Cardiovasc Eng Technol , 5  (4)   334 - 347.    10.1007/s13239-014-0188-4 <https://doi.org/10.1007/s13239-014-0188-4>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1465428/1/The%20%27Sphere%27%3A%20A%20Dedicated%20Bifurcation%20Aneurysm%20Flow-Diverter%20Device..pdf