eprintid: 1465428 rev_number: 44 eprint_status: archive userid: 608 dir: disk0/01/46/54/28 datestamp: 2015-04-10 18:38:13 lastmod: 2021-11-30 00:26:21 status_changed: 2015-04-16 12:47:10 type: article metadata_visibility: show item_issues_count: 0 creators_name: Peach, T creators_name: Cornhill, JF creators_name: Nguyen, A creators_name: Riina, H creators_name: Ventikos, Y title: The 'Sphere': A Dedicated Bifurcation Aneurysm Flow-Diverter Device. ispublished: pub divisions: UCL divisions: B04 divisions: C05 divisions: F45 keywords: CFD, Medical devices, Minimally invasive, Neurovascular, PED, SILK, Shear stress, Stent, Thrombosis, WEB, WSS note: Copyright © 2014 The Author(s). This article is published with open access at Springerlink.com abstract: We present flow-based results from the early stage design cycle, based on computational modeling, of a prototype flow-diverter device, known as the 'Sphere', intended to treat bifurcation aneurysms of the cerebral vasculature. The device is available in a range of diameters and geometries and is constructed from a single loop of NITINOL(®) wire. The 'Sphere' reduces aneurysm inflow by means of a high-density, patterned, elliptical surface that partially occludes the aneurysm neck. The device is secured in the healthy parent vessel by two armatures in the shape of open loops, resulting in negligible disruption of parent or daughter vessel flow. The device is virtually deployed in six anatomically accurate bifurcation aneurysms: three located at the Basilar tip and three located at the terminus bifurcation of the Internal Carotid artery (at the meeting of the middle cerebral and anterior cerebral arteries). Both steady state and transient flow simulations reveal that the device presents with a range of aneurysm inflow reductions, with mean flow reductions falling in the range of 30.6-71.8% across the different geometries. A significant difference is noted between steady state and transient simulations in one geometry, where a zone of flow recirculation is not captured in the steady state simulation. Across all six aneurysms, the device reduces the WSS magnitude within the aneurysm sac, resulting in a hemodynamic environment closer to that of a healthy vessel. We conclude from extensive CFD analysis that the 'Sphere' device offers very significant levels of flow reduction in a number of anatomically accurate aneurysm sizes and locations, with many advantages compared to current clinical cylindrical flow-diverter designs. Analysis of the device's mechanical properties and deployability will follow in future publications. date: 2014-12-01 official_url: http://dx.doi.org/10.1007/s13239-014-0188-4 vfaculties: VENG oa_status: green full_text_type: pub primo: open primo_central: open_green article_type_text: JOURNAL ARTICLE verified: verified_manual elements_source: PubMed elements_id: 1003511 doi: 10.1007/s13239-014-0188-4 pii: 188 language_elements: ENG lyricists_name: Peach, Thomas lyricists_name: Ventikos, Yiannis lyricists_id: TPEAC13 lyricists_id: YVENT41 full_text_status: public publication: Cardiovasc Eng Technol volume: 5 number: 4 pagerange: 334 - 347 issn: 1869-408X citation: Peach, T; Cornhill, JF; Nguyen, A; Riina, H; Ventikos, Y; (2014) The 'Sphere': A Dedicated Bifurcation Aneurysm Flow-Diverter Device. Cardiovasc Eng Technol , 5 (4) 334 - 347. 10.1007/s13239-014-0188-4 <https://doi.org/10.1007/s13239-014-0188-4>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1465428/1/The%20%27Sphere%27%3A%20A%20Dedicated%20Bifurcation%20Aneurysm%20Flow-Diverter%20Device..pdf