eprintid: 1464879 rev_number: 47 eprint_status: archive userid: 608 dir: disk0/01/46/48/79 datestamp: 2015-04-08 03:43:07 lastmod: 2021-12-06 00:29:44 status_changed: 2015-08-25 08:42:44 type: article metadata_visibility: show item_issues_count: 0 creators_name: Devakumar, D creators_name: Stocks, J creators_name: Ayres, JG creators_name: Kirkby, J creators_name: Yadav, SK creators_name: Saville, NM creators_name: Devereux, G creators_name: Wells, JC creators_name: Manandhar, DS creators_name: Costello, A creators_name: Osrin, D title: Effects of antenatal multiple micronutrient supplementation on lung function in mid-childhood: follow-up of a double-blind randomised controlled trial in Nepal ispublished: pub divisions: UCL divisions: B02 divisions: D01 divisions: D13 divisions: G25 keywords: Nepal, child, respiratory function tests, micronutrients. note: Copyright © 2015 by the European Respiratory Society. “This is an author-submitted, peer-reviewed version of a manuscript that has been accepted for publication in the European Respiratory Journal, prior to copy-editing, formatting and typesetting. This version of the manuscript may not be duplicated or reproduced without prior permission from the copyright owner, the European Respiratory Society. The publisher is not responsible or liable for any errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final, copy-edited, published article, which is the version of record, is available without a subscription 18 months after the date of issue publication.” abstract: A randomised trial of prenatal multiple micronutrient supplementation in Nepalese women increased birthweight and weight at 2 years of age in offspring, compared to those born to mothers who only received iron and folic acid supplements. Further follow-up of this cohort provided an opportunity to investigate the effect of antenatal multiple micronutrients on subsequent lung function by measuring spirometry at 7-9 years of age in C: hildren born during the trial. 841 children (80% of the cohort) were seen at mean±sd 8.5±0.4 years. Technically successful spirometry results were obtained in 793 (94.3%) children, 50% of whom had been randomised to micronutrient supplementation. Background characteristics, including anthropometry, were similar in the two allocation groups. Lung function was also similar, mean (95% CI) difference in z-scores (supplementation minus control) was -0.08 (-0.19-0.04), -0.05 (-0.17-0.06) and -0.04 (-0.15-0.07) for forced expiratory volume in 1 s (FEV1), forced vital capacity and FEV1/FVC, respectively. Compared with healthy white children, FEV1 and FVC in the "healthy" Nepalese children were ∼1 (∼13%) z-score lower, with no difference in FEV1/FVC. We conclude that, compared with routine iron and folic acid, multiple micronutrient supplementation during pregnancy has no effect on spirometric lung function in Nepalese children at 8.5 years of age. date: 2015-06-01 official_url: http://dx.doi.org/ 10.1183/09031936.00188914 oa_status: green full_text_type: other primo: open primo_central: open_green verified: verified_manual elements_source: PubMed elements_id: 1018704 doi: 10.1183/09031936.00188914 pii: 09031936.00188914 language_elements: ENG lyricists_name: Costello, Anthony lyricists_name: Devakumar, Delanjathan lyricists_name: Osrin, David lyricists_name: Saville, Naomi lyricists_name: Stocks, Janet lyricists_name: Wells, Jonathan lyricists_id: AMDLC04 lyricists_id: DDEVA49 lyricists_id: DOSRI65 lyricists_id: NMSAV73 lyricists_id: JSTOC65 lyricists_id: JWELL04 full_text_status: public publication: European Respiratory Journal volume: 45 number: 6 pagerange: 1566-1575 issn: 0903-1936 citation: Devakumar, D; Stocks, J; Ayres, JG; Kirkby, J; Yadav, SK; Saville, NM; Devereux, G; ... Osrin, D; + view all <#> Devakumar, D; Stocks, J; Ayres, JG; Kirkby, J; Yadav, SK; Saville, NM; Devereux, G; Wells, JC; Manandhar, DS; Costello, A; Osrin, D; - view fewer <#> (2015) Effects of antenatal multiple micronutrient supplementation on lung function in mid-childhood: follow-up of a double-blind randomised controlled trial in Nepal. European Respiratory Journal , 45 (6) pp. 1566-1575. 10.1183/09031936.00188914 <https://doi.org/10.1183/09031936.00188914>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1464879/1/Stocks_1464879_AAM.pdf