eprintid: 1461024 rev_number: 40 eprint_status: archive userid: 608 dir: disk0/01/46/10/24 datestamp: 2015-08-21 08:33:03 lastmod: 2021-09-26 22:45:09 status_changed: 2015-08-21 08:33:03 type: article metadata_visibility: show item_issues_count: 0 creators_name: Bucar, D creators_name: Lancaster, RW creators_name: Bernstein, J title: Disappearing polymorphs revisited ispublished: pub divisions: UCL divisions: B04 divisions: C06 divisions: F56 note: © 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: Nearly twenty years ago, Dunitz and Bernstein described a selection of intriguing cases of polymorphs that disappear. The inability to obtain a crystal form that has previously been prepared is indeed a frustrating and potentially serious problem for solid-state scientists. This review discusses recent occurrences and examples of disappearing polymorphs (as well as the emergence of elusive crystal forms) to demonstrate the enduring relevance of this troublesome but always captivating phenomenon in solid-state research. A number of these instances have been central issues in patent litigations. This review therefore also highlights the complex relationship between crystal chemistry and the law. date: 2015-06-08 official_url: http://dx.doi.org/10.1002/anie.201410356 vfaculties: VMPS oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Review verified: verified_manual elements_source: Manually entered elements_id: 1009952 doi: 10.1002/anie.201410356 lyricists_name: Bucar, Dejan-Kresimir lyricists_name: Lancaster, Robert lyricists_id: DBUCA58 lyricists_id: RWLAN29 full_text_status: public publication: Angewandte Chemie International Edition volume: 54 number: 24 pagerange: 6972-6993 issn: 1521-3757 citation: Bucar, D; Lancaster, RW; Bernstein, J; (2015) Disappearing polymorphs revisited. Angewandte Chemie International Edition , 54 (24) pp. 6972-6993. 10.1002/anie.201410356 <https://doi.org/10.1002/anie.201410356>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1461024/1/6972_ftp.pdf