eprintid: 1459304 rev_number: 55 eprint_status: archive userid: 608 dir: disk0/01/45/93/04 datestamp: 2014-12-28 19:52:32 lastmod: 2021-09-19 23:34:42 status_changed: 2016-01-25 15:03:34 type: article metadata_visibility: show item_issues_count: 0 creators_name: Blanco-Andujar, C creators_name: Ortega, D creators_name: Southern, P creators_name: Pankhurst, QA creators_name: Thanh, NT title: High performance multi-core iron oxide nanoparticles for magnetic hyperthermia: microwave synthesis, and the role of core-to-core interactions ispublished: pub divisions: UCL divisions: B04 divisions: C05 divisions: F42 divisions: C06 divisions: F60 keywords: Citric Acid, Ferrosoferric Oxide, Hyperthermia, Induced, Magnetic Fields, Magnetite Nanoparticles, Microwaves, Temperature note: This journal is © The Royal Society of Chemistry 2015. This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence abstract: The adoption of magnetic hyperthermia as either a stand-alone or adjunct therapy for cancer is still far from being optimised due to the variable performance found in many iron oxide nanoparticle systems, including commercially available formulations. Herein, we present a reproducible and potentially scalable microwave-based method to make stable citric acid coated multi-core iron oxide nanoparticles, with exceptional magnetic heating parameters, viz. intrinsic loss parameters (ILPs) of up to 4.1 nH m(2) kg(-1), 35% better than the best commercial equivalents. We also probe the core-to-core magnetic interactions in the particles via remanence-derived Henkel and ΔM plots. These reveal a monotonic dependence of the ILP on the magnetic interaction field Hint, and show that the interactions are demagnetising in nature, and act to hinder the magnetic heating mechanism. date: 2015-02-07 date_type: published official_url: http://dx.doi.org/10.1039/c4nr06239f vfaculties: VENG vfaculties: VMPS vfaculties: VMPS oa_status: green full_text_type: pub primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_source: PubMed elements_id: 1000696 doi: 10.1039/c4nr06239f language_elements: eng lyricists_name: Blanco Andujar, Cristina lyricists_name: Nguyen, Thanh lyricists_name: Ortega, Daniel lyricists_name: Pankhurst, Quentin lyricists_name: Southern, Paul lyricists_id: CBLAN83 lyricists_id: TTKNG00 lyricists_id: DORTE04 lyricists_id: QAPAN40 lyricists_id: PJDSO74 actors_name: Gibson, Alice actors_id: AGIBS47 actors_role: owner full_text_status: public publication: Nanoscale volume: 7 number: 5 pagerange: 1768-1775 event_location: England issn: 2040-3372 citation: Blanco-Andujar, C; Ortega, D; Southern, P; Pankhurst, QA; Thanh, NT; (2015) High performance multi-core iron oxide nanoparticles for magnetic hyperthermia: microwave synthesis, and the role of core-to-core interactions. Nanoscale , 7 (5) pp. 1768-1775. 10.1039/c4nr06239f <https://doi.org/10.1039/c4nr06239f>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1459304/1/c4nr06239f.pdf