eprintid: 1459304
rev_number: 55
eprint_status: archive
userid: 608
dir: disk0/01/45/93/04
datestamp: 2014-12-28 19:52:32
lastmod: 2021-09-19 23:34:42
status_changed: 2016-01-25 15:03:34
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Blanco-Andujar, C
creators_name: Ortega, D
creators_name: Southern, P
creators_name: Pankhurst, QA
creators_name: Thanh, NT
title: High performance multi-core iron oxide nanoparticles for magnetic hyperthermia: microwave synthesis, and the role of core-to-core interactions
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F42
divisions: C06
divisions: F60
keywords: Citric Acid, Ferrosoferric Oxide, Hyperthermia, Induced, Magnetic Fields, Magnetite Nanoparticles, Microwaves, Temperature
note: This journal is © The Royal Society of Chemistry 2015. This Open Access Article is licensed under a
Creative Commons Attribution 3.0 Unported Licence
abstract: The adoption of magnetic hyperthermia as either a stand-alone or adjunct therapy for cancer is still far from being optimised due to the variable performance found in many iron oxide nanoparticle systems, including commercially available formulations. Herein, we present a reproducible and potentially scalable microwave-based method to make stable citric acid coated multi-core iron oxide nanoparticles, with exceptional magnetic heating parameters, viz. intrinsic loss parameters (ILPs) of up to 4.1 nH m(2) kg(-1), 35% better than the best commercial equivalents. We also probe the core-to-core magnetic interactions in the particles via remanence-derived Henkel and ΔM plots. These reveal a monotonic dependence of the ILP on the magnetic interaction field Hint, and show that the interactions are demagnetising in nature, and act to hinder the magnetic heating mechanism.
date: 2015-02-07
date_type: published
official_url: http://dx.doi.org/10.1039/c4nr06239f
vfaculties: VENG
vfaculties: VMPS
vfaculties: VMPS
oa_status: green
full_text_type: pub
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_source: PubMed
elements_id: 1000696
doi: 10.1039/c4nr06239f
language_elements: eng
lyricists_name: Blanco Andujar, Cristina
lyricists_name: Nguyen, Thanh
lyricists_name: Ortega, Daniel
lyricists_name: Pankhurst, Quentin
lyricists_name: Southern, Paul
lyricists_id: CBLAN83
lyricists_id: TTKNG00
lyricists_id: DORTE04
lyricists_id: QAPAN40
lyricists_id: PJDSO74
actors_name: Gibson, Alice
actors_id: AGIBS47
actors_role: owner
full_text_status: public
publication: Nanoscale
volume: 7
number: 5
pagerange: 1768-1775
event_location: England
issn: 2040-3372
citation:        Blanco-Andujar, C;    Ortega, D;    Southern, P;    Pankhurst, QA;    Thanh, NT;      (2015)    High performance multi-core iron oxide nanoparticles for magnetic hyperthermia: microwave synthesis, and the role of core-to-core interactions.                   Nanoscale , 7  (5)   pp. 1768-1775.    10.1039/c4nr06239f <https://doi.org/10.1039/c4nr06239f>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1459304/1/c4nr06239f.pdf